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A decline in iron-recycling functions of the splenic red pulp macrophages early during aging is driven by iron loading and involves their damage and a loss in red blood cell clearance capacity.

The novel cathelicidin cathelicidin-MH was identified from the skin of M. heymonsivogt frog, which protects against lipopolysaccharide- and cecal ligation and puncture-induced sepsis, effectively ameliorates multi-organ pathology, especially in lung.

Selection bias, also known as collider bias, likely explains the apparent protective effect of G6PD deficiency against cerebral falciparum malaria.

Isotope tracing, mathematical modeling, and single-cell ATP analysis reveal changes in blood cell metabolism under various conditions, showing stressed hematopoietic stem cells support hematopoiesis through glycolytic ATP production via PFKFB3.

Activation of CaMKII holoenzymes triggers the exchange of subunits with other holoenzymes, including unactivated ones, enabling the calcium-independent phosphorylation and activation of new subunits.

Transcription profiling of activated cells using Phospho-Trap, a new method for identifying activated cells, reveals a critical role for mTOR signaling in red blood cell development and the pathogenesis of anemia

Experimentally validated structural models of ACKR1-LukE and CCR5-LukE complexes reveal the critical contributions of sulfotyrosine binding sites and divergent loops of Staphylococcus aureus leukotoxins to the recognition of chemokine receptors.

Rab11a-mediated endosomal trafficking in macrophages regulates potassium channel localization and activity at the cell surface and the downstream activation of the inflammasome and is a potential therapeutic target in acute or chronic inflammatory states.

Measuring surface proteins on extracellular vesicles enables quantitative comparison of different isolation methods and optimization of size exclusion chromatography.

SPOT-MAS (screening for the presence of tumor by methylation and size) is an affordable and effective multi-cancer early detection test analyzing multiple features of circulating tumor DNA.