1,311 results found
    1. Evolutionary Biology
    2. Physics of Living Systems

    Evolution of irreversible somatic differentiation

    Yuanxiao Gao et al.
    Irreversible differentiation into somatic cells is evolutionarily optimal if changing cell phenotype is costly, a few somatic cells already improve the organism's performance, and the organism is large enough.
    1. Neuroscience

    Switch-like and persistent memory formation in individual Drosophila larvae

    Amanda Lesar et al.
    A new computer controlled behavioral assay and integrated training chamber for individual Drosophila larvae shows that larvae learn all at once and create long-term memories that last overnight.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation

    Solène N Lefebvre et al.
    A pentameric channel-receptor was studied by combining allosteric mutations, electrophysiology, fluorescent reporters and normal mode analysis, to dissect the long-range allosteric couplings specifically involved in its pre-activation and activation.
    1. Immunology and Inflammation

    Structural variability and concerted motions of the T cell receptor – CD3 complex

    Prithvi R Pandey et al.
    The orientation of the TCR extracellular domain is highly variable and coupled to characteristic structural changes throughout the TCR - CD3 complex.
    1. Neuroscience

    A projectome of the bumblebee central complex

    Marcel Ethan Sayre et al.
    Serial-section electron microscopy uncovers the intricate neural network of the bumblebee central complex, revealing highly conserved projection patterns as well as novel circuit elements potentially unique to bees.
    1. Neuroscience

    ‘Fearful-place’ coding in the amygdala-hippocampal network

    Mi-Seon Kong et al.
    By recording simultaneous spike trains from fear-responsive basal amygdala (BA) and place-responsive dorsal hippocampus (dHPC) neurons in rats foraging for food in a risky predatory situation, a novel BA-dHPC circuit coding mechanism for interfacing danger and place information was revealed.
    1. Cell Biology
    2. Developmental Biology

    MACF1 controls skeletal muscle function through the microtubule-dependent localization of extra-synaptic myonuclei and mitochondria biogenesis

    Alireza Ghasemizadeh et al.
    Maintenance of peripheral myonuclei patterning in skeletal myofibers is dependent on the regulation of microtubules dynamic and nuclei motion and is essential for proper neuromuscular junction integrity and mitochondria homeostasis.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A modified fluctuation assay reveals a natural mutator phenotype that drives mutation spectrum variation within Saccharomyces cerevisiae

    Pengyao Jiang et al.
    Certain mutational signatures vary in their contribution to genetic variation across the yeast phylogeny due to genetically encoded natural mutator phenotypes whose activity can be directly measured in the lab.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective

    Mona Seifert et al.
    High-throughput and ultra-stable magnetic tweezers reveal that Remdesivir induces a long-lived backtrack pause upon incorporation by the coronavirus polymerase, and SARS-CoV-2 is able to evade interferon-induced antiviral ddhCTP.
    1. Developmental Biology
    2. Neuroscience

    Unbiased identification of novel transcription factors in striatal compartmentation and striosome maturation

    Maria-Daniela Cirnaru et al.
    RNAseq and ATACseq are utilized to identify transcription factors participating in striatal compartmentation into striosome and matrix, and roles for Stat1, Olig2, and Foxf2 are validated in vitro and in vivo.

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