358 results found
    1. Cell Biology
    2. Medicine

    Quantitative mapping of human hair greying and reversal in relation to life stress

    Ayelet M Rosenberg, Shannon Rausser ... Martin Picard
    A method to profile hair pigmentation patterns establishes a new approach for psychobiological studies and links metabolic changes to greying in humans.
    1. Cell Biology
    2. Medicine

    Pigmentation: Watching hair turn grey

    Michael P Philpott
    Analysing changes in hair pigmentation may lead to a better understanding of the impacts of ‘life events’ on human biology and aging.
    Version of Record
    Insight
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Coordinated hedgehog signaling induces new hair follicles in adult skin

    Xiaoyan Sun, Alexandra Are ... Maria Kasper
    Hedgehog-pathway activation in adjacent epithelial and stromal cells, but not in epithelial or stromal cells alone, enables the generation of functional de novo hair follicles in unwounded adult mouse skin.
    1. Computational and Systems Biology
    2. Developmental Biology

    A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning

    Qixuan Wang, Ji Won Oh ... Maksim V Plikus
    Regional differences in activator and inhibitor signals alter hair cycle pace across mouse skin and produce unique fur renewal 'landscapes', with fastest renewal on the ventrum and slowest renewal on the ear pinnae.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolution: How (some) mammals lost their hair

    Matthew D Dean
    An approach that allows scientists to identify regions of the genome that evolved faster in hairless mammals reveals candidate genetic mechanisms that gave rise to hairlessness.
    Version of Record
    Insight
    1. Plant Biology

    RPG acts as a central determinant for infectosome formation and cellular polarization during intracellular rhizobial infections

    Beatrice Lace, Chao Su ... Thomas Ott
    Infectosomes enabling polar progression of infection threads in legume roots require the symbioisis-related RPG protein that functions as an organizer of these structures.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Complementary evolution of coding and noncoding sequence underlies mammalian hairlessness

    Amanda Kowalczyk, Maria Chikina, Nathan Clark
    Studying the genomes of mammals with sparse hair covering identifies specific genes and regulatory regions responsible for the formation of hair and skin, some of which were previously unrecognized.
    1. Computational and Systems Biology
    2. Developmental Biology

    Elastic force restricts growth of the murine utricle

    Ksenia Gnedeva, Adrian Jacobo ... A J Hudspeth
    Computational modeling and molecular-biological analysis reveal the role of mechanical force and downstream Yap signaling in growth control during the development and regeneration of sensory epithelium of the inner ear.
    1. Neuroscience

    Computation identifies structural features that govern neuronal firing properties in slowly adapting touch receptors

    Daine R Lesniak, Kara L Marshall ... Ellen A Lumpkin
    Computer simulations show that the firing patterns of branched touch receptors can be set in part by the organization of their sensory endings in the skin.
    1. Cancer Biology
    2. Cell Biology

    Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy

    Leying Chen, Qing You ... Shiyi Zhang
    Modulation of dermal adipocytes contributes to skin homeostasis and provides a promising new therapeutic strategy in the treatment of EGFRI-related skin disorders.

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