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    1. Computational and Systems Biology
    2. Developmental Biology

    A balance of positive and negative regulators determines the pace of the segmentation clock

    Guy Wiedermann et al.
    Computational modelling together with experimental manipulation indicate that the stability and turnover of activated Notch is inextricably linked to the regulation of the pace of segmentation clock gene expression in the presomitic mesoderm.
    1. Genetics and Genomics
    2. Neuroscience

    Neuropeptide ACP facilitates lipid oxidation and utilization during long-term flight in locusts

    Li Hou et al.
    CRISPR/Cas 9 technology and multiple-omics study reveal an essential regulatory role of neuropeptide ACP in lipid utilization related to prolonged flight of locusts.
    1. Immunology and Inflammation

    Resident macrophages acquire innate immune memory in staphylococcal skin infection

    Reinhild Feuerstein et al.
    Resident dermal Mφ are programmed locally, independently of bone-marrow monocytes during Staphylococcus aureus infection, leading to transiently increased resistance, which is limited by a decrease in macrophage life span.
    1. Cancer Biology
    2. Developmental Biology

    Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth

    Tiemo J Klisch et al.
    Aberrant phosphorylation of tyrosine 78 on Atoh1 via Jak2 is responsible for sonic hedgehog type medulloblastoma growths in vivo.
    1. Cell Biology
    2. Neuroscience

    Unconventional secretory processing diversifies neuronal ion channel properties

    Cyril Hanus et al.
    Imaging, quantitative immunoblotting and mass spectrometry reveal that hundreds of surface-expressed neuronal membrane proteins exhibit atypical glycosylation profiles, resulting in changes in protein half-life and synaptic responses.
    1. Cell Biology
    2. Neuroscience

    The synaptic ribbon is critical for sound encoding at high rates and with temporal precision

    Philippe Jean et al.
    The synaptic ribbon regulates calcium channel clustering and proper vesicle dynamics at cochlear inner hair cells to ensure precise sound encoding.
    1. Physics of Living Systems

    Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis

    Lu Ma et al.
    The Munc18-1 protein promotes formation of the t-SNARE complex and the half-zippered SNARE complex, two rate-limiting steps of SNARE assembly, to enhance membrane fusion.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Global, cell non-autonomous gene regulation drives individual lifespan among isogenic C. elegans

    Holly E Kinser et al.
    Expression of almost half of a library of fluorescent reporters distinguish long- from short-lived individual Caenorhabditis elegans, suggesting that organism-wide differences in gene expression drive future lifespan.
    1. Genetics and Genomics
    2. Neuroscience

    Temporal transcriptomics suggest that twin-peaking genes reset the clock

    William G Pembroke et al.
    RNA sequencing reveals the finer details of circadian variation in the mammalian master pacemaker over 24 hours, which suggests that transcriptional timing influences clock resetting mechanisms.
    1. Neuroscience

    Separable pupillary signatures of perception and action during perceptual multistability

    Jan W Brascamp et al.
    When conscious visual perception changes, the observer's pupils simultaneously signal the accompanying change in visual cortical representation, and specific neuromodulatory activity that helps translate the altered visual experience into behavior.