5,802 results found
  1. Meta-Research: Weak evidence of country- and institution-related status bias in the peer review of abstracts

    Mathias Wullum Nielsen et al.
    A preregistered survey experiment spanning six disciplines has found weak evidence of bias in favour of authors from high-status countries and institutions.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation

    Shi Yun Yeo et al.
    Loss-of-function screening identified transglutaminase 2 (TGM2) as a putative tumor suppressor in the TP53 pathway and revealed that TGM2-mediated autophagy and CDKN1A-mediated cell cycle arrest are two critical barriers that prevent oncogenic transformation.
    1. Genetics and Genomics

    Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis

    Satish K Nandakumar et al.
    A gene-centric functional screen uncovers biological mechanisms underlying genome-wide association study signals for human red blood cell traits.
    1. Developmental Biology

    Lola regulates Drosophila adult midgut homeostasis via non-canonical hippo signaling

    Xue Hao et al.
    The transcription factor Lola is defined as a non-canonical Hippo signaling component essential for Drosophila midgut homeostasis via its interaction with Warts and suppression on Dref and SkpA expression levels.
    1. Neuroscience

    Decoupling sensory from decisional choice biases in perceptual decision making

    Daniel Linares et al.
    Perceptual decision making, even in simple scenarios, is affected by sensory and decisional choice biases.
    1. Immunology and Inflammation
    2. Physics of Living Systems

    Light-based tuning of ligand half-life supports kinetic proofreading model of T cell signaling

    Doug K Tischer, Orion David Weiner
    Direct control of ligand binding half-life with light shows that lifetime strongly affects T cell signaling.
    1. Computational and Systems Biology
    2. Developmental Biology

    A balance of positive and negative regulators determines the pace of the segmentation clock

    Guy Wiedermann et al.
    Computational modelling together with experimental manipulation indicate that the stability and turnover of activated Notch is inextricably linked to the regulation of the pace of segmentation clock gene expression in the presomitic mesoderm.
    1. Cancer Biology
    2. Developmental Biology

    Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth

    Tiemo J Klisch et al.
    Aberrant phosphorylation of tyrosine 78 on Atoh1 via Jak2 is responsible for sonic hedgehog type medulloblastoma growths in vivo.
    1. Cell Biology

    Centrosome age regulates kinetochore–microtubule stability and biases chromosome mis-segregation

    Ivana Gasic et al.
    The presence of cenexin at the old centrosome imposes a functional asymmetry on the mitotic spindle that impacts chromosome alignment and segregation.
    1. Cell Biology

    The role of IMP dehydrogenase 2 in Inauhzin-induced ribosomal stress

    Qi Zhang et al.
    The small molecule Inauhzin possesses a dual targeting ability, and activates p53 by targeting two enzymes—SIRT1 and IMP dehydrogenase 2 (IMPDH2)—which are highly expressed in human cancers.

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