1,730 results found
    1. Neuroscience

    Selective and regulated trapping of nicotinic receptor weak base ligands and relevance to smoking cessation

    Anitha P Govind et al.
    The smoking cessation drug varenicline (Chantix) and other weak base ligands reduce a4b2-type nicotinic receptor (a4b2R) upregulation through slow intracellular release due to selective trapping in acidic vesicles that contain a4b2Rs.
    1. Neuroscience

    Object vision to hand action in macaque parietal, premotor, and motor cortices

    Stefan Schaffelhofer, Hansjörg Scherberger
    The cortical grasping circuit separates but shares visual and motor processes to transform object attributes into appropriate hand movements.
    1. Structural Biology and Molecular Biophysics

    Structural dynamics of E. coli single-stranded DNA binding protein reveal DNA wrapping and unwrapping pathways

    Sukrit Suksombat et al.
    Single-molecule force and fluorescence spectroscopy reveal the structural states and dynamics of E. coli single-stranded DNA binding proteins and the energy landscape of the nucleo–protein complex.
    1. Neuroscience

    Experience shapes activity dynamics and stimulus coding of VIP inhibitory cells

    Marina Garrett et al.
    VIP inhibitory neurons are active in response to novel images but are suppressed by familiar stimuli and show ramping activity when expected stimuli are omitted.
    1. Neuroscience

    Serial grouping of 2D-image regions with object-based attention in humans

    Danique Jeurissen et al.
    The human visual system groups the individual features of objects together into a coherent whole via a serial, attention-demanding process.
    1. Computational and Systems Biology
    2. Neuroscience

    Movement initiation and grasp representation in premotor and primary motor cortex mirror neurons

    Steven Jack Jerjian et al.
    Mirror neurons, including corticospinal neurons, in primary motor cortex of macaque monkeys, clearly dissociate between execution and observation of grasping actions while ventral premotor cortex (F5) maintains a similar representation.
    1. Neuroscience

    A synergy-based hand control is encoded in human motor cortical areas

    Andrea Leo et al.
    The human brain encodes coordinated patterns of joint movements – synergies – to increase the efficiency with which it can control complex hand movements.
    1. Ecology
    2. Plant Biology

    Determining the scale at which variation in a single gene changes population yields

    Erica McGale et al.
    Variation in the gene NaMPK4 in plant populations increases reproductive yield, an effect which appears to be independent of soil water availability, neighbor-scale interactions and associations with arbuscular mycorrhizal fungi.
    1. Neuroscience

    Unusual prism adaptation reveals how grasping is controlled

    Willemijn D Schot et al.
    Adapting single-digit movements in opposite directions makes people open their grip in accordance with the adaptations of the individual digits, showing that grip aperture arises from goal-directed movements of the digits rather than being controlled independently.
    1. Ecology

    Linking spatial patterns of terrestrial herbivore community structure to trophic interactions

    Jakub Witold Bubnicki et al.
    The spatial interactions between humans, large carnivores and herbivores cascade down in a complex but predictable way to lower trophic levels affecting regeneration of tree species in a temperate forest.

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