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Building on previous work (Zanini et al, 2015), deep-sequencing is used to show that HIV persistence during suppressive antiretroviral therapy, the main hurdle for HIV cure, is due to homeostatic proliferation and longevity of infected cells rather than ongoing virus replication.

Phosphate accumulation in zinc-deficient Arabidobsis shoots is regulated by a pathway involving the transcription factor bZIP23, the phospholipid-remodelling enzyme LPCAT1 and the transporter PHT1;1.

Sequence analyses show a pfhrp3 deletion mechanism involves duplication of chromosome 11 segment, which is normally removed via negative selection, and specific conditions are needed for spread including low transmission.

A combination of composite-likelihood and gene network-based methods to investigate the impact of Denisovan introgression on the evolution of complex (i.e., polygenic) adaptive traits in high-altitude populations of Tibetan/Sherpa ancestry.

Neither the presence nor the intensity of Hematodinium sp. parasitisation drives co-infection occurrence, severity, or diversity in the ecologically ubiquitous shore crab, Carcinus maenas.

New modelling, statistics, and experiments show that cellular populations of mitochondrial DNA (mtDNA) evolve during development according to solvable stochastic dynamics involving binomial partitioning and random turnover, facilitating a predictive and quantitative theory of the mtDNA bottleneck.

Endoplasmic reticulum proteostasis factors enhance the mutational tolerance of influenza hemagglutinin, a model secretory pathway protein and therapeutic target, particularly improving the fitness of temperature-sensitive variants.

Single-cell transcriptomics of intraocular infiltrate in human HLA-B27-associated active anterior uveitis shows a unique composition and phenotype of leukocytes preferentially affecting dendritic cells.

Female-inherited supernumerary chromosomes that lack a male-inherited homolog are transmitted to all meiotic products instead of the expected half, which indicates an additional amplification of unpaired chromosomes during meiosis.

Arabidopsis shows extensive genetic diversity in germination time distributions, which can be explained by the underlying ABA/GA network functioning as a noisy bistable switch.