Kiss1ARH neurons transition from synchronous to burst firing under preovulatory levels of E2, causing a shift from peptidergic to glutamatergic transmission that drives the GnRH surge through enhanced glutamate neurotransmission.
Time-resolved tmFRET revealed structural and energetic changes induced by ligand binding with full agonist cAMP and partial agonist cGMP in the cyclic nucleotide-binding domain of the bacterial ion channel SthK.
Francesca Torelli, Diogo M da Fonseca ... Moritz Treeck
Secreted effector proteins of Toxoplasma gondii parasites create a supportive immune environment in mice, allowing individually less fit mutants to thrive and evade detection by in vivo CRISPR screens.
Cell cycle arrest in response to a double-stranded break is initially maintained by the DNA damage checkpoint and later by the spindle assembly checkpoint.
NALCN and TRPC6 drive the subthreshold depolarization of VTA DA neurons and down regulation of TRPC6 contributes to reduced VTA DA neuron firing and chronic stress-induced depression-like behavior of mice.
A single-nucleus atlas of bone repair uncovers the trajectories of periosteal skeletal stem/progenitor cells in response to fracture and identifies injury-induced fibrogenic cells as intermediate osteochondroprogenitors and key paracrine regulators.
Hannah R Martin, Anna Lysakowski, Ruth Anne Eatock
A striking and consequential conductance in vestibular type I hair cells is finally shown to depend on a little-known Shaker subunit that contributes to conventional conductances in other hair cells.
