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In vitro fertilization-conceived murine embryos show evidence of oxidative and metabolic stress with alteration in lactic acid metabolism.

HCAR1 knockout mice are unable to initiate brain tissue repair after a hypoxic-ischemic injury.

Designer transmembrane peptides precisely control chimeric antigen receptor signaling strength and are insulated from undesired interactions with endogenous receptors.

Biophysical and structural studies reveal how two inhibitory antibodies targeting CSP on malaria-causing Plasmodium vivax parasites lock its intrinsically flexible repeat into predominant coiled conformations, contributing molecular details of Pv inhibition by antibodies to enable structure-based engineering of PvCSP-based vaccines.

Biochemical and cell biological data suggest a model of nascent integrin adhesion complex formation based on synergistic phase separation of pathways surrounding the focal adhesion kinase (FAK) and the adaptor protein p130Cas.

At most physiological concentrations, the short-chain fatty acids propionate and butyrate affect histone acetylation by modifying and activating the acetyltransferase p300/CBP, rather than by inhibiting histone deacetylases.

Epithelial cells coordinate integrin signaling with protrusion via a two-protein module, with one protein defining localization and downstream signaling, the other serving as a phosphorylation switch and providing negative feedback.

Analyses show that happiness is not associated with the reward prediction errors resulting from decisions but instead with belief updating and learning the structure of the world.

A comprehensive structural analysis of inhibitory murine antibody 3D11 binding to Plasmodium berghei circumsporozoite protein reveals common mechanisms of antibody evolution in mammals against Plasmodium parasites.

Estrogen aggravates mammary involution through lysosome-mediated cell death, neutrophil recruitment via CXCR2 signalling, neutrophil-mediated inflammation and adipocyte repopulation.