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    1. Medicine

    Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice

    Ying Ann Chiao et al.
    Mitochondrial-targeted SS-31 peptide ameliorates mitochondrial dysfunction and rescues pre-existing cardiac dysfunction in old mice, supporting the translational potential of mitochondrial protective interventions to treat age-related diseases.
    1. Biochemistry and Chemical Biology

    Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms

    Gregory M Solis et al.
    Directly targeting the ribosome to attenuate translation partly mimics the integrated stress response, increasing lifespan and preserving protein folding capacity even in older individuals with dysfunctional stress response signaling.
    1. Developmental Biology

    Targeting senescent cells enhances adipogenesis and metabolic function in old age

    Ming Xu et al.
    Senescent cells contribute to age-related fat dysfunction and can directly impair healthy fat progenitor function, in part, via the secretion of activin A.
    1. Epidemiology and Global Health

    Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm

    Daniel W Belsky et al.
    Methylation pace of aging is a novel measure requiring only a blood sample that clinical-trial and observational studies can use to test if treatments modify how fast participants are aging.
    1. Cell Biology
    2. Developmental Biology

    Endogenous siRNAs promote proteostasis and longevity in germline-less Caenorhabditis elegans

    Moran Cohen-Berkman et al.
    Endo-siRNAs slow down the rate of aging and enable the maintenance of a responsive heat shock response in aging germline-less Caenorhabditis elegans.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Reduced expression of C/EBPβ-LIP extends health and lifespan in mice

    Christine Müller et al.
    Reduced expression of a single transcription factor is sufficient to improve fitness and health at old age and increases the lifespan in female mice.
    1. Stem Cells and Regenerative Medicine

    Cohesin controls intestinal stem cell identity by maintaining association of Escargot with target promoters

    Aliaksandr Khaminets et al.
    Cohesin-regulated 3D genome conformation controls activity of transcription factor Escargot in intestinal stem cells, prevents premature differentiation into enterocytes and maintains intestinal homeostasis.
    1. Cell Biology
    2. Neuroscience

    Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons

    Jose F Moruno-Manchon et al.
    G-quadruplex DNA regulates autophagy in neurons.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Recurrent turnover of senescent cells during regeneration of a complex structure

    Maximina H Yun et al.
    Senescent cells are recurrently induced during limb regeneration in salamanders and subsequently eliminated by a highly efficient mechanism of macrophage-dependent surveillance.
    1. Biochemistry and Chemical Biology

    Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans

    Nicole L Jenkins et al.
    As worms age reduced glutathione together with increased ferrous iron increases frailty and leads to ferroptosis, which is amenable to therapeutic intervention.