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    1. Developmental Biology

    Pilot study of large-scale production of mutant pigs by ENU mutagenesis

    Tang Hai et al.
    ENU mutagenesis in pigs is an efficient strategy to introduce mutations at the whole-genome level and mutants have been generated on a large scale for agricultural production and biomedical research.
    1. Neuroscience

    MeCP2 regulates Tet1-catalyzed demethylation, CTCF binding, and learning-dependent alternative splicing of the BDNF gene in Turtle

    Zhaoqing Zheng et al.
    Loss of MeCP2 function negatively impacts Tet1 and CTCF binding thereby negatively impacting learning-dependent DNA methylation and alternative splicing regulation.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Limitations to photosynthesis by proton motive force-induced photosystem II photodamage

    Geoffry A Davis et al.
    Storage of solar energy in the thylakoid electrical field by photosynthesis in vivo can substantially destabilize charge-separated states in photosystem II, leading to singlet oxygen production and photodamage, contributing to loss of productivity, especially under fluctuating light experienced in the field.
    1. Neuroscience

    Intracortical Microstimulation: Regaining the senses of touch and movement

    Victor de Lafuente
    Artificially activating certain neurons in the cortex can make a tetraplegic patient feel naturalistic sensations of skin pressure and arm movement.
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    1. Human Biology and Medicine

    Point of View: Competency-based assessment for the training of PhD students and early-career scientists

    Michael F Verderame et al.
    A method to assess the training of scientists, based on a set of 10 core competencies, is proposed.
    1. Neuroscience

    Deletion of KCNQ2/3 potassium channels from PV+ interneurons leads to homeostatic potentiation of excitatory transmission

    Heun Soh et al.
    Loss of potassium channel activity from fast-spiking interneurons increases their excitability leading to unexpectedly increased fast excitatory transmission and seizure susceptibility.
    1. Neuroscience

    Learning: The cerebellum influences vocal timing

    Court Hull
    We are starting to understand how the cerebellum contributes to vocal learning in songbirds.
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