1,989 results found
    1. Developmental Biology

    Live imaging of heart tube development in mouse reveals alternating phases of cardiac differentiation and morphogenesis

    Kenzo Ivanovitch et al.
    Tissue-level coordination of cardiac progenitor cells in the early mouse embryo produces a temporal compartmentalization of differentiation and morphogenesis essential for heart tube formation.
    1. Developmental Biology

    Calcium handling precedes cardiac differentiation to initiate the first heartbeat

    Richard CV Tyser et al.
    High-resolution live imaging reveals how and when the mouse heart first starts to beat during development and how the onset of beating impacts on heart muscle cell maturation and heart formation.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent

    Shanshan Ai et al.
    During heart maturation, embryonic ectoderm development as a chromatin remodeler triggers transcriptional silencing, while H3K27me3 is a passenger that is not sufficient for gene silencing.
    1. Chromosomes and Gene Expression

    Regulation of alternative polyadenylation by Nkx2-5 and Xrn2 during mouse heart development

    Keisuke Nimura et al.
    A tissue-specific transcription factor is involved in the regulation of alternative polyadenylation in conjunction with a transcription termination factor.
    1. Developmental Biology

    Glycosylphosphatidylinositol biosynthesis and remodeling are required for neural tube closure, heart development, and cranial neural crest cell survival

    Marshall Lukacs et al.
    Anchoring of proteins to the cell membrane through the glycosylphosphatidylinositol (GPI) anchor is critical for the survival of the cells that will give rise to the brain and face.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Cardiac Hypertrophy: A tail of translational regulation

    Gillian A Gray, Nicola K Gray
    An RNA-binding protein called PABPC1 has an important role in determining protein synthesis rates and hypertrophy in the heart.
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    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Poly(A) tail length regulates PABPC1 expression to tune translation in the heart

    Sandip Chorghade et al.
    A poly(A) tail-based regulatory mechanism dynamically controls PABPC1 protein synthesis in cardiomyocytes and thereby titrates cellular translation in response to developmental and hypertrophic cues.
    1. Developmental Biology
    2. Human Biology and Medicine

    High throughput in vivo functional validation of candidate congenital heart disease genes in Drosophila

    Jun-yi Zhu et al.
    A high-throughput functional validation system for large numbers of candidate disease genes enables in vivo functional testing of specific gene variants.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Dissection of zebrafish shha function using site-specific targeting with a Cre-dependent genetic switch

    Kotaro Sugimoto et al.
    A versatile invertible gene trap vector is generated and inserted into a defined genomic locus in zebrafish via homologous recombination, demonstrating an efficient genetic approach to performing conditional knockout analysis.

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