1,743 results found
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock

    Maria Azkanaz et al.
    Heat shock induces relocalization of epigenetic modifiers to the nucleolus, which acts as a dedicated protein quality control center that is indispensable for recovery of epigenetic regulators and epigenetic modifications.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response

    Joanna Krakowiak et al.
    Dynamic regulation of the heat shock response depends on a negative feedback loop in which Hsf1 activates expression of Hsp70 and Hsp70 specifically and directly represses Hsf1 transactivation.
    1. Genetics and Genomics

    Diversification of the Caenorhabditis heat shock response by Helitron transposable elements

    Jacob M Garrigues et al.
    Helitron transposable elements, by providing high density transcription factor binding sites upstream of host genes, have diversified the heat shock response within and among Caenorhabditis species.
    1. Cell Biology
    2. Computational and Systems Biology

    Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation

    Xu Zheng et al.
    Quantitative dissection of the roles of chaperone binding and phosphorylation in regulating heat shock factor 1 leads to a predictive model of the dynamics of the yeast heat shock response.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Transient intracellular acidification regulates the core transcriptional heat shock response

    Catherine G Triandafillou et al.
    When translation stops, cells require intracellular acidification to turn on the conserved heat shock response during stress, and stress-triggered acidification (common in eukaryotes) is adaptive, promoting cell and population fitness.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular mechanism of thermosensory function of human heat shock transcription factor Hsf1

    Nikolai Hentze et al.
    Heat-induced local unfolding allows Hsf1 to form trimers and bind to DNA, which depends on Hsf1 concentration and is promoted, not inhibited, by Hsp90.
    1. Structural Biology and Molecular Biophysics

    Interplay of disordered and ordered regions of a human small heat shock protein yields an ensemble of ‘quasi-ordered’ states

    Amanda F Clouser et al.
    Multiple iso-energetic-specific interactions involving the intrinsically-disordered region of sHSP HSPB1 define a quasi-ordered state, providing insights into inherited disease-associated mutations within the region that are thought to be disordered.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The translation elongation factor eEF1A1 couples transcription to translation during heat shock response

    Maria Vera et al.
    Eukaryotic translation elongation factor 1A1 controls the process of heat shock response, from transcriptional activation of the HSP70 gene, to HSP70 mRNA stabilization, nuclear export, and translation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Heat Shock: When pH comes to the rescue

    Davi Gonçalves et al.
    In starving yeast exposed to thermal stress, a transient drop in intracellular pH helps to trigger the heat shock response.
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    1. Cell Biology

    Cytoplasmic protein misfolding titrates Hsp70 to activate nuclear Hsf1

    Anna E Masser et al.
    Hsp70 restricts DNA binding activity of Hsf1 to control the width and amplitude of the heat-shock regulon.

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