A thermal stability-based proteomic analysis identifies cytoplasmic PEBP1 as a mediator of mitochondrial dysfunction-induced stress response, highlighting its potential role in cellular adaptation mechanisms.

Thousands of cell-type-specific split-GAL4 driver lines and a massive, searchable image collection enable Drosophila neuroscientists to target neurons of interest with increased precision.

Unveiling the circuit organization and functional roles of endopiriform neurons projecting to the ventral CA1.

Breast luminal epithelial cells are the hotspots of aging-associated changes, which prime aged epithelia for oncogenic gene activation and may explain individual differences in breast cancer susceptibility due to the aging-associated increase in gene expression variances in luminal epithelia.

Single-molecule tracking at scale, analyzing millions of cells and thousands of compounds per day, demonstrates that measuring protein motion provides mechanistic insights relevant to drug discovery.