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    1. Genetics and Genomics
    2. Neuroscience

    Increased processing of SINE B2 ncRNAs unveils a novel type of transcriptome deregulation in amyloid beta neuropathology

    Yubo Cheng et al.
    SINE RNAs are implicated in amyloid beta molecular pathology in hippocampus.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation

    Bence Hajdusits et al.
    The McsB kinase is critical for protein quality control in Gram-positive bacteria, assembling a gated phosphorylation chamber during heat-shock conditions to selectively mark misfolded proteins for degradation.
    1. Cell Biology
    2. Developmental Biology

    Protein aggregates are associated with replicative aging without compromising protein quality control

    Juha Saarikangas, Yves Barral
    The aging lineage of budding yeast is differentiated by an early-appearing protein deposit that promotes protein quality control.
    1. Chromosomes and Gene Expression

    A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C. elegans

    Wei Jiang et al.
    A gene regulatory program regulating thermal stress response and organismic death.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Phosphatidylinositol 3-phosphate and Hsp70 protect Plasmodium falciparum from heat-induced cell death

    Kuan-Yi Lu et al.
    Phosphatidylinositol 3-phosphate interacts with PfHsp70-1 and stabilizes the Plasmodium digestive vacuole under febrile temperatures.
    1. Cell Biology
    2. Computational and Systems Biology

    Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation

    Xu Zheng et al.
    Quantitative dissection of the roles of chaperone binding and phosphorylation in regulating heat shock factor 1 leads to a predictive model of the dynamics of the yeast heat shock response.
    1. Cell Biology
    2. Computational and Systems Biology

    Heat Shock Response: A model for handling cell stress

    Laura Le Breton, Matthias P Mayer
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    1. Computational and Systems Biology
    2. Developmental Biology

    A re-inducible gap gene cascade patterns the anterior–posterior axis of insects in a threshold-free fashion

    Alena Boos et al.
    The body axis of insects is divided into different fates using a self-regulatory and threshold-free mechanism.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A conserved histidine modulates HSPB5 structure to trigger chaperone activity in response to stress-related acidosis

    Ponni Rajagopal et al.
    Small decreases in pH associated with cellular stress conditions unleash a cryptic mode of client binding in a ubiquitously expressed human small heat shock protein that is more effective at delaying client aggregation.
    1. Neuroscience

    Dopamine neurons drive fear extinction learning by signaling the omission of expected aversive outcomes

    Ximena I Salinas-Hernández et al.
    Dopamine signaling is necessary for normal fear extinction learning.