Forward genetic screens define a novel genetic landscape by which diverse, unrelated autism risk genes may converge to commonly affect the robustness of synaptic transmission.

Computational modeling of a central decision neuron of Drosophila reveals an electrotonically compact architecture that is ideally suited to support efficient memory storage within a stochastically connected memory circuit.

Allele-specific expression, natural antisense transcripts, and developmental gene expression, but not RNA editing or developmental hourglass, act in concert to shape the transcriptome during the fruiting body formation of complex multicellular fungi.

Adjusting key parameters of the synaptic transmission at a single defined synapse of the visual circuit can affect properties of this circuit and animal behavior.

METTL3-mediated m6A modification maintains proper cell lineage specification during skin epithelium morphogenesis by coupling transcription and translation of key regulatory pathways.

In vivo genetic experiments show that aberrant expression of a transcription factor can compromise the functionality of neurons which is important to better understand the potential mechanisms underlying neuropathologies.

The localization of Rad53 cell cycle checkpoint kinase to many gene promoters and the dynamic changes in response to replication stress suggests that the kinase may coordinate genome stability and gene expression.

A novel two-step model for integrin activation primed by Cas during cell migration and spreading on multiple extracellular matrix ligands.

Multimodal spectroscopy (smFRET, EPR, SAXS, and SANS) and integrative structural modeling reveal large-scale domain rearrangements in human guanylate binding protein 1 (hGBP1) that are driving forces for the formation of oligomers that enable its biological function in innate immune defense.

The natural compounds cordycepin and mycophenolic acid stimulate alternative polyadenylation through opposing effects on transcriptional rate.