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    1. Chromosomes and Gene Expression

    A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C. elegans

    Wei Jiang, Yuehua Wei ... Dengke K Ma
    A gene regulatory program regulating thermal stress response and organismic death.
    1. Cell Biology

    Diet-induced loss of adipose hexokinase 2 correlates with hyperglycemia

    Mitsugu Shimobayashi, Amandine Thomas ... Michael N Hall
    A proteomics screening in mouse adipose tissue shows that loss of adipose Hexokinase 2 is a mechanism of obesity-induced insulin insensitivity.
    1. Plant Biology

    Glutaredoxin regulation of primary root growth is associated with early drought stress tolerance in pearl millet

    Carla de la Fuente, Alexandre Grondin ... Laurent Laplaze
    Increased primary root growth in pearl millet is correlated with early water stress tolerance, an important constraint in agrosystems in the Sahel, and is associated with the regulation of root cell elongation by a glutaredoxin.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    The RAM signaling pathway links morphology, thermotolerance, and CO2 tolerance in the global fungal pathogen Cryptococcus neoformans

    Benjamin J Chadwick, Tuyetnhu Pham ... Xiaorong Lin
    In the fungal pathogen Cryptococcus neoformans, the RAM pathway, potentially through post-transcriptional regulation, plays an essential role in adaptation to host temperature and CO2.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Phosphatidylinositol 3-phosphate and Hsp70 protect Plasmodium falciparum from heat-induced cell death

    Kuan-Yi Lu, Charisse Flerida A Pasaje ... Emily Derbyshire
    Phosphatidylinositol 3-phosphate interacts with PfHsp70-1 and stabilizes the Plasmodium digestive vacuole under febrile temperatures.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Arabidopsis FORGETTER1 mediates stress-induced chromatin memory through nucleosome remodeling

    Krzysztof Brzezinka, Simone Altmann ... Isabel Bäurle
    Environmentally-mediated gene induction is extended beyond the duration of an external cue by sustaining a nucleosome-depleted chromatin structure.
    1. Chromosomes and Gene Expression

    The genetic basis of aneuploidy tolerance in wild yeast

    James Hose, Leah E Escalante ... Audrey P Gasch
    A single gene allele underlies differences in aneuploidy tolerance in yeast.
    1. Cell Biology
    2. Developmental Biology

    N-myc downstream regulated gene 1 (ndrg1) functions as a molecular switch for cellular adaptation to hypoxia

    Jong S Park, Austin M Gabel ... Rachel Brewster
    Lactate-Ndrg1a signaling protects the kidney from hypoxic injury and functions partly by inducing reversible degradation of the ATP-demanding sodium-potassium ATPase pump.
    1. Plant Biology

    A regulatory module controlling stress-induced cell cycle arrest in Arabidopsis

    Naoki Takahashi, Nobuo Ogita ... Masaaki Umeda
    Arabidopsis deploys the core signalling module that perceives distinct stress signals, such as DNA damage and heat stresses, and represses G2/M-specific genes, thereby causing cell cycle arrest.