280 results found
    1. Computational and Systems Biology
    2. Developmental Biology

    Single-cell transcriptomics of the Drosophila wing disc reveals instructive epithelium-to-myoblast interactions

    Nicholas J Everetts et al.
    A single-cell atlas of the developing Drosophila wing disc at two time points enables a detailed understanding of the signals exchanged between different cell populations during development.
    1. Evolutionary Biology

    Group phenotypic composition in cancer

    Jean-Pascal Capp et al.
    Tumoral group phenotypic compositions and their relationships with the fitness of individual malignant cells in different ecological contexts represent crucial, previously unexplored dynamics in tumor progression.
    1. Developmental Biology

    A gradient of Wnt activity positions the neurosensory domains of the inner ear

    Magdalena Żak, Nicolas Daudet
    Manipulations of Wnt signalling in the chicken embryo reveal how it controls in a dose-dependent manner the formation of the neurosensory territories of the early developing inner ear.
    1. Cell Biology
    2. Developmental Biology

    Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex

    Eric T Hall et al.
    Sonic Hedgehog is transported inside cytonemes with co-receptors that promote contact-mediated signal delivery to initiate rapid, receptor-dependent responses in recipient cells.
    1. Cell Biology
    2. Neuroscience

    Ciliary neuropeptidergic signaling dynamically regulates excitatory synapses in postnatal neocortical pyramidal neurons

    Lauren Tereshko et al.
    Neuropeptidergic signaling via cilia-localized receptors dynamically regulates excitatory synaptic drive in postnatal rat neocortical pyramidal neurons.
    1. Cancer Biology
    2. Evolutionary Biology

    Pervasive duplication of tumor suppressors in Afrotherians during the evolution of large bodies and reduced cancer risk

    Juan M Vazquez, Vincent J Lynch
    Duplication of tumor suppressor genes contributed to the evolution of large, long-lived elephants.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Glycine acylation and trafficking of a new class of bacterial lipoprotein by a composite secretion system

    Christopher Icke et al.
    AatD is a novel acyltransferase that mediates N-palmitoylation of glycine, a process not previously described, that results in the secretion of lipoproteins to the bacterial cell surface.
    1. Developmental Biology

    Retrograde ERK activation waves drive base-to-apex multicellular flow in murine cochlear duct morphogenesis

    Mamoru Ishii et al.
    Live-cell imaging and mathematical modeling reveal the physical basis of collective cell migration underlying spiral cochlear duct formation during murine inner ear development.
    1. Developmental Biology

    Differential activation of JAK-STAT signaling reveals functional compartmentalization in Drosophila blood progenitors

    Diana Rodrigues et al.
    Comprehensive developmental in situ analysis of the Drosophila lymph gland provides markers highlighting blood progenitor diversity and reveals that JAK-STAT signaling prevents posterior progenitor differentiation, promoting survival after immune challenge.
    1. Immunology and Inflammation
    2. Medicine

    Perinatal granulopoiesis and risk of pediatric asthma

    Benjamin A Turturice et al.
    Perinatal granulopoiesis and cord blood serum PGLYRP-1, a specific granule protein, are altered prior to onset of childhood asthma and provide potential targets for early identification of at-risk populations.

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