179 results found
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Interferon lambda 4 impacts the genetic diversity of hepatitis C virus

    M Azim Ansari et al.
    Interferon lambda 4, a protein part of the innate immune response, drives major amino acids selection in patients chronically infected with hepatitis C virus.
    1. Neuroscience

    The cerebellum is involved in processing of predictions and prediction errors in a fear conditioning paradigm

    Thomas Michael Ernst et al.
    Pronounced cerebellar activation during unexpected omission of a potentially harmful event suggests that the cerebellum has to be added to the neural network processing prediction errors underlying emotional associative learning.
    1. Neuroscience

    A human subcortical network underlying social avoidance revealed by risky economic choices

    Johannes Schultz et al.
    The subjective value of engaging in human social situations, and amygdala and nucleus accumbens activation and their connectivity during social decision-making, vary with social anxiety traits.
    1. Neuroscience

    Closed-loop optogenetic activation of peripheral or central neurons modulates feeding in freely moving Drosophila

    Pierre-Yves Musso et al.
    The Sip-Triggered Optogenetic Behavior Enclosure (STROBE) produces robust behaviors via activation of peripheral or central neurons in the fly, and mimics key features of feeding driven by chemical taste ligands.
    1. Computational and Systems Biology
    2. Neuroscience

    Characterizing functional pathways of the human olfactory system

    Guangyu Zhou et al.
    Human primary olfactory cortical regions can be parcellated into anatomically distinct areas based on whole-brain functional connectivity profiles, suggesting distinct, parallel functional pathways in the human olfactory system.
    1. Evolutionary Biology

    The genomes of polyextremophilic cyanidiales contain 1% horizontally transferred genes with diverse adaptive functions

    Alessandro W Rossoni et al.
    Horizontal gene transfer (HGT) analysis in polyextremophile red algae (Cyanidiales) provides explanations for the nonexistence of cumulative effects and eukaryotic pangenomes, and highlights differences between HGT and native genes.
    1. Biochemistry and Chemical Biology

    The dynamic conformational landscape of the protein methyltransferase SETD8

    Shi Chen et al.
    Integrated experimental-computational approaches were implemented to reveal the dynamic conformational landscape of a biologically relevant protein methyltransferase SETD8 for functional annotation.
    1. Neuroscience

    Functional and anatomical specificity in a higher olfactory centre

    Shahar Frechter et al.
    The Drosophila lateral horn, a higher olfactory brain area, contains >165 genetically defined cell types with stereotyped odour responses across animals and improved odor categorisation compared with their inputs.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Global donor and acceptor splicing site kinetics in human cells

    Leonhard Wachutka et al.
    Transient transcriptome sequencing and kinetic modeling suggest how the kinetics and yield of RNA splicing are encoded in the human genome.
    1. Cancer Biology
    2. Cell Biology

    Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation

    Karoliina Stefanius et al.
    Exosomes secreted from pancreatic cancer cells can function as a classic initiator in the multi-step cellular transformation process.

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