7,778 results found
    1. Cell Biology
    2. Neuroscience

    2018 Gairdner Awards: The past, present and future of light-gated ion channels and optogenetics

    Sheena A Josselyn
    Research into light-gated ion channels called channelrhodospins laid the foundations for the development of optogenetics, a technique that has gone on to revolutionize neuroscience.
    1. Neuroscience

    Brain Development: The impact of light during the night

    Sophia TC Leung et al.
    Exposing chicks to one hour of light during the night disrupts the releaseof a hormone that is needed by cells in the developing brain to survive.
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    1. Ecology
    2. Evolutionary Biology

    Physiology: The highs and lows of bird flight

    Jon Harrison
    Bar-headed geese lower their flight metabolic rates to fly in low-oxygen conditions.
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    1. Developmental Biology
    2. Neuroscience

    Genetic specification of left–right asymmetry in the diaphragm muscles and their motor innervation

    Camille Charoy et al.
    Analysis of embryonic mouse diaphragm reveals muscle and nerve left–right asymmetries set by a Nodal-dependent genetic cascade, which imprints different molecular signatures to left and right motoneurons that shape their innervation pattern.
    1. Genetics and Genomics

    Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

    Aline Jelenkovic et al.
    Genetic variance of adult human height shows a generally increasing trend across the birth-year cohorts but heritability estimates do not present any clear pattern of secular changes over a century.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain

    Boris Brumshtein et al.
    Ligands that bind dimers of light chain variable domains inhibit the formation of amyloid fibrils.
    1. Cell Biology
    2. Developmental Biology

    First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic β-cell mass

    Guangliang Wang et al.
    A novel high-throughput, whole organism chemical screening platform was used to identify existing drugs that increase pancreatic beta-cell mass in zebrafish, implicating unique roles for the NF-κB and serotonergic signaling pathways in regulating pancreatic biology.
    1. Neuroscience

    The impact of pathological high-frequency oscillations on hippocampal network activity in rats with chronic epilepsy

    Laura A Ewell et al.
    A novel framework for separating normal and pathological high-frequency oscillations in animals with epilepsy uncovers new mechanisms for impaired hippocampal network function.
    1. Neuroscience

    MagC, magnetic collection of ultrathin sections for volumetric correlative light and electron microscopy

    Thomas Templier
    The augmentation of resin-embedded sample blocks with magnetic resin allows remote actuation of ultrathin sections and deposition at high packing density onto silicon wafers for correlative light and electron microscopy.
    1. Cell Biology
    2. Developmental Biology

    Epidermal cell turnover across tight junctions based on Kelvin's tetrakaidecahedron cell shape

    Mariko Yokouchi et al.
    The three dimensional structure of epidermal cells in the stratum granulosum provides the basis for the homeostasis of the tight junction barrier during cell turnover in the skin.

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