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    1. Structural Biology and Molecular Biophysics

    Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

    Wenjuan Zhang et al.
    Cryo-EM structures of heparin-induced tau filaments differ from those observed in neurodegenerative disease, illustrating their structural versatility, and prompting questions about the relevance of in vitro amyloid models.
    1. Computational and Systems Biology
    2. Neuroscience

    A connectome and analysis of the adult Drosophila central brain

    Louis K Scheffer et al.
    New reconstruction methods are used to create a publicly available dense reconstruction of the neurons and chemical synapses of central brain of Drosophila, with analysis of its graph properties.
    1. Cell Biology
    2. Neuroscience

    Reconstruction of genetically identified neurons imaged by serial-section electron microscopy

    Maximilian Joesch et al.
    A new pipeline of electron microscopy techniques reduces the time required to visualize genetically targeted neurons and their connections by two orders of magnitude.
    1. Developmental Biology

    A predictive model of asymmetric morphogenesis from 3D reconstructions of mouse heart looping dynamics

    Jean-François Le Garrec et al.
    A precise sequence of left-right asymmetries, combined with mechanical constraints, is sufficient to drive the looped morphogenesis of the embryonic heart tube, with potential impact for congenital heart defects.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1 at 3.7 angstrom resolution

    Luis Miguel Díaz-Santín et al.
    An atomic model of the 3744-residue Tra1 protein reveals multiple transcription activator binding sites, its integration within the SAGA chromatin coactivator complex, and a striking similarity to DNA-repair factor DNA-PKcs.
    1. Cell Biology
    2. Genetics and Genomics

    A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing

    Weina Zhang et al.
    Farrerol promotes the efficiency of CRISPR/Cas9-mediated genome editing in both cells and embryos.
    1. Cell Biology

    NuMA recruits dynein activity to microtubule minus-ends at mitosis

    Christina L Hueschen et al.
    At mitosis, NuMA recruits dynein-dynactin to microtubule minus-ends, enabling robust microtubule clustering and the emergence of spindle poles.
    1. Structural Biology and Molecular Biophysics

    A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery

    Zev A Ripstein et al.
    Understanding of bacterial protein degradation is illuminated by cryo-EM structures of the substrate-bound ClpXP complex from Neisseria meningitidis at 2.3 to 3.3 Å resolution.
    1. Evolutionary Biology

    Expansion of the fatty acyl reductase gene family shaped pheromone communication in Hymenoptera

    Michal Tupec et al.
    A fatty acyl reductase gene family expansion in the Hymenoptera crown group led to recruitment of novel pheromone-biosynthetic enzymes and is linked to evolution of pheromone marking behavior.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases

    Han Han et al.
    Structural and biochemical studies indicate that AAA+ ATPase employ a general mechanism to translocate a variety of substrates, including extended polypeptides, hairpins, crosslinked chains, and chains conjugated to other molecules.