3,971 results found
    1. Cell Biology
    2. Plant Biology

    Reticulon proteins modulate autophagy of the endoplasmic reticulum in maize endosperm

    Xiaoguo Zhang et al.
    Plant reticulons bind Atg8 under ER stress to promote reticulophagy and ameliorate ER stress in the maize endosperm.
    1. Cell Biology
    2. Immunology and Inflammation

    Microtubule plus-end dynamics link wound repair to the innate immune response

    Clara Taffoni et al.
    Microtubules orchestrate wound repair and innate immune response in the Caenorhabditis elegans epidermis.
    1. Chromosomes and Gene Expression

    Translational initiation in E. coli occurs at the correct sites genome-wide in the absence of mRNA-rRNA base-pairing

    Kazuki Saito et al.
    E. coli ribosomes incapable of base-pairing with the Shine-Dalgarno sequence are still selective for annotated start sites, indicating these sites are hard-wired for initiation by other mRNA features.
    1. Neuroscience

    Sound exposure dynamically induces dopamine synthesis in cholinergic LOC efferents for feedback to auditory nerve fibers

    Jingjing Sherry Wu et al.
    Based on the animal’s recent history of sound exposure, cholinergic auditory brainstem neurons dynamically regulate dopamine synthesis for inhibitory feedback to the inner ear.
    1. Computational and Systems Biology
    2. Neuroscience

    Sodium channels implement a molecular leaky integrator that detects action potentials and regulates neuronal firing

    Marco A Navarro et al.
    Kinetic interactions between sodium channels and auxiliary factors create a molecular computational engine that can sense and regulate cellular excitability.
    1. Neuroscience
    2. Physics of Living Systems

    Variability in locomotor dynamics reveals the critical role of feedback in task control

    Ismail Uyanik et al.
    Animals rely on sensory feedback rather than the precise tuning in the nervous system to achieve robust behavioral performances.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress

    Mable Lam et al.
    Death receptor 5 can directly sense misfolded proteins downstream of the endoplasmic reticulum to provide a quality control mechanism that executes apoptosis and prevents further production of misfolded proteins.
    1. Cancer Biology

    Functional heterogeneity of lymphocytic patterns in primary melanoma dissected through single-cell multiplexing

    Francesca Maria Bosisio et al.
    Multiplexing and digital analysis of melanoma tissue describe functionally the microenvironment associated with brisk/non-brisk infiltrates and expose the functional incongruences of this morphological classification currently in use for tumor-infiltrating lymphocytes.
    1. Neuroscience

    β11-12 linker isomerization governs acid-sensing ion channel desensitization and recovery

    Matthew L Rook et al.
    The rotation of the β11-12 linker is a crucial control point for acid-sensing ion channel gating and motion of this linker is required for the channel to desensitize.

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