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    1. Medicine

    Estimating bone marrow adiposity from head MRI and identifying its genetic architecture

    Tobias Kaufmann, Pål Marius Bjørnstad ... Timothy Hughes
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cancer Biology

    Metastasis of colon cancer requires Dickkopf-2 to generate cancer cells with Paneth cell properties

    Jae Hun Shin, Jooyoung Park ... Alfred LM Bothwell
    DKK2 is crucial for the development of lysozyme-expressing cancer cells with Paneth cell characteristics necessary for liver metastasized colon cancer growth.
    1. Immunology and Inflammation

    CD131 Contributes to Ulcerative Colitis Pathogenesis by Promoting Macrophage Infiltration

    Zhiyuan Wu, Lindi Liu ... Xiaodong Tan
    Not revised
    Reviewed Preprint v1
    • Incomplete
    1. Stem Cells and Regenerative Medicine

    Periosteal skeletal stem cells can migrate into the bone marrow and support hematopoiesis after injury

    Tony Marchand, Kemi E Akinnola ... Kira Gritsman
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Microbiology and Infectious Disease

    Longitudinal transcriptional changes reveal genes from the natural killer cell-mediated cytotoxicity pathway as critical players underlying COVID-19 progression

    Matias A Medina, Francisco Fuentes-Villalobos ... Maria Ines Barria
    Longitudinal transcriptomic analysis of unvaccinated patients reveals that early NK cell cytotoxicity activation distinguishes mild from severe COVID-19, supporting the relevance of concerted innate–adaptive immune responses against the virus.
    1. Cell Biology

    GDF2 and BMP10 coordinate liver cellular crosstalk to maintain liver health

    Dianyuan Zhao, Ziwei Huang ... Li Tang
    Hepatic stellate cells play a central role in maintaining liver health by mediating cell-to-cell crosstalk via the production of GDF2 and BMP10.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Alteration of long and short-term hematopoietic stem cell ratio causes myeloid-biased hematopoiesis

    Katsuyuki Nishi, Taro Sakamaki ... Masanori Miyanishi
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    • Inadequate
    1. Computational and Systems Biology
    2. Cancer Biology

    Altered thymic niche synergistically drives the massive proliferation of malignant thymocytes

    Erika Tsingos, Advaita M Dick, Baubak Bajoghli
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cancer Biology
    2. Computational and Systems Biology

    Robust estimation of cancer and immune cell-type proportions from bulk tumor ATAC-Seq data

    Aurélie Anne-Gaëlle Gabriel, Julien Racle ... David Gfeller
    EPIC-ATAC accurately quantifies cell-type heterogeneity in tumor bulk ATAC-Seq samples using reliable cell-type specific chromatin accessibility markers for the major cell types found in tumor microenvironments.
    1. Immunology and Inflammation

    A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency

    Yuji Miyatake, Tomokatsu Ikawa ... Ai Kotani
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
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