A model of early postnatal bacterial meningitis in the mouse demonstrates the transcriptome responses of each of the major meningeal cell types and should prove useful in dissecting the pathophysiology of bacterial meningitis in human infants.
A pain-relaying ion channel on a hypersensitive population of sensory neurons can instead elicit sensations of itch in both fish and mice when directly activated, providing a novel model of itch transduction.
Rediet Zewdu, Elnaz Mirzaei Mehrabad ... Eric L Snyder
Genetically engineered murine models reveal novel mechanisms of cell identity regulation in lung cancer and provide insights into the complex interplay between lineage specifiers and oncogenic signaling pathways in this disease.
Yingying Zhang, Jocelyn Charlton ... Alexander Meissner
Ectopic expression of Dnmt3b leads to wide-spread CpG island hypermethylation that is largely defined by chromatin state and has some distinct features when compared to the cancer methylome.
Jamie Moore-Fried, Mahinder Paul ... Gregoire Lauvau
CD169+ macrophages in the bone marrow of malaria-infected mice uptake infected red blood cells, and establish a functional interaction that is required to activate plasmacytoid dendritic cells to secrete type I interferon and leave the bone marrow.
A mitochondria-based 'priming' of stemness happens by fine-tuned repression of the level or activity of the master regulator of mitochondrial fission, Drp1, which supports carcinogen-induced transformation in a keratinocyte model.
Orphan ATM kinase-domain missense mutations are unexpectedly common and form a potent oncogenic event and a biomarker for Topo-isomerase I inhibitor based therapy.
