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    1. Stem Cells and Regenerative Medicine
    2. Immunology and Inflammation

    MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice

    Jimmy L Zhao et al.
    Chronic and excessive inflammation can lead to exhaustion of the supply of hematopoietic stem cells and to myeloid malignancies in mice, mimicking important aspects of the myelodysplastic syndrome found in humans.
    1. Cancer Biology
    2. Developmental Biology

    Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations

    Shaina N Porter et al.
    Age-specific transcriptional responses to Flt3-ITD and cooperating Flt3/Runx1 mutations cause hematopoietic stem cell depletion and myeloid progenitor expansion during adult, but not fetal/neonatal, stages of development.
    1. Chromosomes and Gene Expression
    2. Stem Cells and Regenerative Medicine

    Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis

    Jasmine C Wong et al.
    Immature hematopoietic cells from mice with a large segmental deletion found in human myeloid malignancies exhibit cardinal features of myelodysplastic syndrome.
    1. Stem Cells and Regenerative Medicine

    ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response

    Richard H Chapple et al.
    Estrogen is a systemic factor that promotes hematopoietic regeneration by activating the unfolded protein responses.
    1. Stem Cells and Regenerative Medicine

    Adult zebrafish Langerhans cells arise from hematopoietic stem/progenitor cells

    Sicong He et al.
    Adult zebrafish Langerhans cells are derived from hematopoietic stem/progenitor cells but not Erythro-myeloid progenitors.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development

    Wenwen Zhou et al.
    The conserved mechanism of Notch down-regulation by endo-lysosomal trafficking plays important roles in the proliferation and differentiation of stem and progenitor cells during embryogenesis or organogenesis in vertebrates.
    1. Immunology and Inflammation

    A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice

    Fei Tang et al.
    A novel population of hematopoietic cells unmasked by mTORC1 inactivation reveals a new mechanism of innate immune tolerance and a new consequence of defective hematopoiesis.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability

    Judith Schütte et al.
    A computer model built on insights gained from comprehensive experimental analysis reveals mechanisms of blood stem cell regulation.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    lncRNA requirements for mouse acute myeloid leukemia and normal differentiation

    M Joaquina Delás et al.
    A comprehensive analysis of long noncoding RNAs in the hematopoietic system reveals their dynamic regulation and a loss-of-function screen identifies some required for leukemia progression and involved in normal myeloid differentiation.
    1. Immunology and Inflammation

    Cell-density independent increased lymphocyte production and loss rates post-autologous HSCT

    Mariona Baliu-Piqué et al.
    Altered lymphocyte dynamics after hematopoietic stem cell transplantation cannot solely be explained by low lymphocyte numbers.