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Zebrafish provide unique resources for the study of the tumor microenvironment.

Comprehensive single-cell transcriptome analysis reveals global and tissue-specific aging markers and characterizes the heterogeneous aging status of different cell types and tissues in mouse.

Specific tissue environments provide selective pressures that give rise to distinct Ras oncogenic dosage in primary liver tumours and their metastatic-like outgrowths.

As macrophages are involved in various aspects of non-small cell lung cancer development and progression it is crucial to develop appropriate 3D co-culture platforms for modeling immune cell-tumor cell interactions, leading to more efficacious macrophage-focused immunotherapies.

The common human HAQ,AQ alleles suppress STING1 gain-of-function mutation-induced chronic STING1 inflammation in mice.

Antagonistic signaling by the kinases PI3K and Itpkb limits the kinetics and enforces the Notch-dependence of beta-selection – the most important cell-fate determining process in alpha beta T cell development.

Genetically engineered murine models reveal novel mechanisms of cell identity regulation in lung cancer and provide insights into the complex interplay between lineage specifiers and oncogenic signaling pathways in this disease.

Inhibition of a single fibroblast-associated transcription factor, namely Paired-related Homeobox Protein 1 (PRRX1), is sufficient to dampen lung fibrogenesis.

LPS pre-exposure is tissue protective during a subsequent lethal E. coli peritonitis by long-term modulation the bone marrow B-cell and neutrophil pool which affects neutrophil tissue damaging properties and therapeutic activation of Cxcr4 promotes tissue damage control during sepsis.