Replicating experimental evolution from ancestral proteins shows that historical contingency steadily overwhelms chance and necessity as the primary cause of evolutionary variation in molecular sequences on long phylogenetic timescales.

A molecular profiling approach to quantify transcripts and proteins from identical samples allows study of molecular effects of maturation, sexual differentiation and the endogenous circalunar clock in a marine worm.

Neurogenic progenitor cells surrounding the eye placode generate neurons that migrate over long distances to the developing octopus brain.

During the evolution of insect lineages, a signaling pathway dedicated to pathogen defense was co-opted for a new role in embryonic patterning.

Understanding novel cell types and their evolutionary history is re-evaluated using single nuclei transcriptomic approaches and their inferred underlying gene regulatory networks.

Seastar larvae can regenerate their nervous system by specifying cells to express the gene sox2 to enter neural progenitor states that then follow embryonic gene regulatory modes to form new neurons.

Human chromosome-microtubule attachments are stabilised by Astrin-mediated dynamic delivery of PP1 phosphatase to the attachment site, which ensures the normal segregation of chromosomes.

Heparan Sulfate Proteoglycans function as receptors for the R-spondins, a family of growth factors that amplify the strength of WNT signaling during development and in adult stem cells.

Developmental regulatory mechanisms for peripheral nervous system formation appear to be conserved in ascidians despite extensive genomic divergence after 390 MY of separate evolution.

The transcriptional control system of a sea urchin gene reveals the deep evolutionary conservation of a gene regulatory network underlying morphogenesis.