36 results found
    1. Developmental Biology and Stem Cells
    2. Cell Biology

    Cells must express components of the planar cell polarity system and extracellular matrix to support cytonemes

    Hai Huang, Thomas B Kornberg
    Different cytoneme types require specific heparan sulfate proteoglycans (HSPGs) that are stratified within the extracellular matrix in Drosophila.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    R-spondins can potentiate WNT signaling without LGRs

    Andres M Lebensohn, Rajat Rohatgi
    R-spondins 2 and 3 can potentiate WNT signaling in the absence of LGRs through interactions with ZNRF3/RNF43 E3 ubiquitin ligases and heparan sulfate proteoglycans, defining two alternative modes of R-spondin-mediated signaling.
    1. Ecology
    2. Genomics and Evolutionary Biology

    Transcriptome analysis illuminates the nature of the intracellular interaction in a vertebrate-algal symbiosis

    John A Burns et al.
    The endosymbiosis between an alga and the spotted salamander shows several parallels to invertebrate-algal symbioses as well as to pathogen associations in vertebrate animals.
    1. Computational and Systems Biology
    2. Developmental Biology and Stem Cells

    Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling

    Andres M Lebensohn et al.
    A systematic genetic analysis comprising seven genome-wide screens in haploid human cells uncovered new regulatory mechanisms at most levels in the WNT signaling pathway.
    1. Biophysics and Structural Biology
    2. Human Biology and Medicine

    The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding

    Simon Mysling et al.
    Building on previous work (Mysling et al., 2016), it is shown that angiopoietin-like protein 4 (ANGPTL4) inhibits lipoprotein lipase activity by catalyzing the unfolding of its hydrolase domain.
    1. Neuroscience

    Tracing neuronal circuits in transgenic animals by transneuronal control of transcription (TRACT)

    Ting-hao Huang et al.
    A new method that will allow researchers to visualize and genetically manipulate synaptically connected neurons in a brain circuit.
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    A functional genomics screen in planarians reveals regulators of whole-brain regeneration

    Rachel H Roberts-Galbraith et al.
    A gene expression-guided functional screen identifies factors and cell types that regulate diverse aspects of neural regeneration in planarians.
    1. Developmental Biology and Stem Cells

    Reactive oxygen species-dependent Toll/NF-κB activation in the Drosophila hematopoietic niche confers resistance to wasp parasitism

    Isabelle Louradour et al.
    In the Drosophila hematopoietic microenvironment, a regulatory network involving Toll/NF-B, EGFR signaling and reactive oxygen species controls blood cell production in response to immune stress.
    1. Cancer Biology
    2. Cell Biology

    Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells

    Michiel van Veen et al.
    GDE3 is a transmembrane GPI-specific phospholipase C that sheds the urokinase receptor (uPAR) from the cell surface resulting in loss of uPAR function in breast cancer cells and reduced tumor growth.
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos

    Amanda D Yzaguirre et al.
    Ras-GAP activity suppresses the hemogenic potential of the embryonic heart.

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