946 results found
    1. Neuroscience

    Functional brain alterations following mild-to-moderate sensorineural hearing loss in children

    Axelle Calcus et al.
    Mild-to-moderate sensorineural hearing loss causes changes in the neurophysiological functioning that emerge during adolescence, as suggested by both cross-sectional and longitudinal designs.
    1. Chromosomes and Gene Expression

    Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss

    Meritxell Espino Guarch et al.
    SLC7A8 a neutral amino acid transporter has a key role in the maintenance of hearing during aging and its absence causes early onset of hearing loss.
    1. Neuroscience

    Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production

    Magali Macchi et al.
    Heparan sulfate synthesis by mature oligodendrocytes creates a protective and permissive environment controling microglia and oligodendrocyte progenitors reactivation during remyelination.
    1. Cell Biology
    2. Developmental Biology

    R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling

    Ramin Dubey et al.
    Heparan Sulfate Proteoglycans function as receptors for the R-spondins, a family of growth factors that amplify the strength of WNT signaling during development and in adult stem cells.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin

    Martina Brunati et al.
    Hepsin is the first protease identified to modulate specific cleavage and secretion of a Zona Pellucida domain protein, uromodulin.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B

    Timo Vögtle et al.
    Heparan sulfates in the vessel wall bind and regulate signaling from the megakaryocyte/platelet-specific inhibitory receptor G6b-B, a critical regulator of platelet homeostasis.
    1. Neuroscience

    Behavioral training promotes multiple adaptive processes following acute hearing loss

    Peter Keating et al.
    Training enables adult humans to rapidly adapt their sound localization abilities to unilateral hearing loss by combining different strategies that rely on partially distinct neurophysiological substrates.
    1. Developmental Biology
    2. Neuroscience

    Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons

    Sebastian Poliak et al.
    The Netrin-1 and ephrin-B2 proteins act synergistically in the developing nervous system.
    1. Developmental Biology
    2. Neuroscience

    Ephrin-A/EphA specific co-adaptation as a novel mechanism in topographic axon guidance

    Felix Fiederling et al.
    A distinctive novel mechanism of ephrin-A/EphA signaling modulation in retinal growth cones ensures concurrent quantitative accuracy and adaptability of topographic hardwiring.
    1. Cell Biology
    2. Neuroscience

    The 133-kDa N-terminal domain enables myosin 15 to maintain mechanotransducing stereocilia and is essential for hearing

    Qing Fang et al.
    Two myosin 15 isoforms are required separately for the development and long-term maintenance of hearing.

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