28 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    The genetic architecture of NAFLD among inbred strains of mice

    Simon T Hui et al.
    A system genetics approach reveals a unique molecular signature of non-alcoholic fatty liver disease in mice and identifies novel genetic factors affecting hepatic steatosis.
    1. Developmental Biology

    Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism

    Gianpaolo Rando et al.
    Glucocorticoid receptor directly regulates the transcriptional activity of peroxisome proliferator-activated alpha (PPARα) before birth in anticipation of the sudden shifts in the postnatal nutrient source and metabolic demands.
    1. Genetics and Genomics

    Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease

    Robert N Helsley et al.
    Loss of function of membrane-bound O-acyltransferase 7 (MBOAT7), but not transmembrane channel-like 4 (TMC4), promotes hepatic steatosis.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Coalescing beneficial host and deleterious antiparasitic actions as an antischistosomal strategy

    John D Chan et al.
    Engagement of both host and parasite signaling pathways proves a novel approach for developing improved anti-parasitic therapies.
    1. Developmental Biology

    A novel source of arterial valve cells linked to bicuspid aortic valve without raphe in mice

    Lorriane Eley et al.
    Identification of a novel source of progenitor cells that form arterial valve leaflets and that, when disrupted, can lead to bicuspid arterial valve, the most common human cardiac malformation.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation

    Daniil Alpern et al.
    Physical and functional interactions between HNF4A and TAF4 coordinate HNF4A genomic occupancy with pre-initiation complex formation to activate post-natal hepatocyte gene expression.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

    Lars Plate et al.
    Small molecule proteostasis regulators that activate the unfolded protein response transcription factor ATF6 reduce the secretion of amyloid disease-associated proteins.
    1. Cell Biology

    Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion

    Xin Rong et al.
    The enzyme Lpcat3 plays a unique role in the incorporation of arachidonic acid into membranes, which is required for the production of lipoproteins.
    1. Cell Biology

    Defective STIM-mediated store operated Ca2+ entry in hepatocytes leads to metabolic dysfunction in obesity

    Ana Paula Arruda et al.
    Store operated calcium entry is defective in hepatocytes of obese mice, and restoring this process is sufficient to improve glucose metabolism.
    1. Genetics and Genomics

    Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice

    Shunxing Rong et al.
    SREBP-2 directly regulates genes involved in cholesterol homeostasis and indirectly regulates fatty acid synthesis through the production of a ligand responsible for the activation of LXR and SREBP-1c.

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