332 results found
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts

    Ruihua Ma et al.
    Mouse genetic approaches show that multiple Wnt endothelial sources orchestrate the spatiotemporal distribution of hepatocyte functions during liver maturation and respecify metabolic zonation during liver repair.
  1. Point of view: Motivating participation in open science by examining researcher incentives

    Sarah E Ali-Khan et al.
    A survey of researchers at the Montreal Neurological Institute and Hospital provides insights into the challenges and opportunities involved in adopting an open science policy across an entire patient-oriented academic institution.
    1. Genetics and Genomics
    2. Human Biology and Medicine

    Point of View: Bioengineering horizon scan 2020

    Luke Kemp et al.
    20 emerging issues in bioengineering that will have profound impacts on society have been identified.
    1. Cell Biology
    2. Computational and Systems Biology

    Science Forum: The Human Cell Atlas

    Aviv Regev et al.
    Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
    1. Computational and Systems Biology

    Research: Bias in the reporting of sex and age in biomedical research on mouse models

    Oscar Flórez-Vargas et al.
    A text-mining study suggests that about half of the papers reporting the results of experiments on mice do not report the sex and age of the mice.
    1. Developmental Biology

    SOX2 regulates acinar cell development in the salivary gland

    Elaine Emmerson et al.
    Establishment of the acinar lineage in the salivary gland requires SOX2 and parasympathetic nerves.
    1. Neuroscience

    Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress

    Abigail M Polter et al.
    Rats exposed to a single stressful event experience days-long constitutive activation of the kappa opioid receptor at inhibitory synapses in part of the brain’s reward system, which increases their drug-seeking behavior.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Coalescing beneficial host and deleterious antiparasitic actions as an antischistosomal strategy

    John D Chan et al.
    Engagement of both host and parasite signaling pathways proves a novel approach for developing improved anti-parasitic therapies.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Flatworm-specific transcriptional regulators promote the specification of tegumental progenitors in Schistosoma mansoni

    George R Wendt et al.
    The specification of tegumental progenitor cells in Schistosoma mansoni relies on a pair of flatworm-specific transcription factors that are related to genes regulating epidermal specification in free-living flatworms.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors

    Yang Yang et al.
    High-resolution structures of HIV-1 RT in complex with two newly developed non-nucleoside inhibitors explain how they retain antiviral activities against drug-resistant RT mutants with considerably reduced susceptibility to rilpivirine.

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