93 results found
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Neolithic and medieval virus genomes reveal complex evolution of hepatitis B

    Ben Krause-Kyora et al.
    Ancient hepatitis B virus (HBV) genomes were reconstructed from up to 7000-year-old Stone Age human skeletons, suggesting a long-time complex co-evolution with human populations.
    1. Microbiology and Infectious Disease

    Unravelling the history of hepatitis B virus genotypes A and D infection using a full-genome phylogenetic and phylogeographic approach

    Evangelia-Georgia Kostaki et al.
    Considerable differences are observed in the global dissemination patterns of HBV-D and HBV-A, the genotypes of which have putative origins in North Africa/Middle East (HBV-D) and the Middle East/Central Asia (HBV-A).
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Hepatitis B virus core protein allosteric modulators can distort and disrupt intact capsids

    Christopher John Schlicksup et al.
    Small molecule antivirals that drive assembly of HBV capsid protein can also bind to pre-assembled capsids causing them to change morphology or even break, suggesting a complex transduction of binding effects across the capsid.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

    Huan Yan et al.
    Biochemical and genetic tests have revealed that a liver protein called NTCP is a functional receptor for hepatitis B and D viruses, which should lead to an improved understanding of the infections caused by these viruses and assist the development of new intervention strategies.
    1. Structural Biology and Molecular Biophysics

    All-atom molecular dynamics of the HBV capsid reveals insights into biological function and cryo-EM resolution limits

    Jodi A Hadden et al.
    All-atom molecular dynamics of the HBV capsid supports a role for structural asymmetry in biological function, reveals the potential for triangular pores to mediate cellular signaling, and indicates that capsid flexibility may limit resolution attainable by cryo-EM.
    1. Evolutionary Biology

    The Natural History of Model Organisms: Insights into mammalian biology from the wild house mouse Mus musculus

    Megan Phifer-Rixey, Michael W Nachman
    Studies of the house mouse Mus musculus have provided important insights into mammalian biology, and efforts to study wild house mice and to create new inbred strains from wild populations have the potential to increase its usefulness as a model system.
    1. Neuroscience

    v-SNARE transmembrane domains function as catalysts for vesicle fusion

    Madhurima Dhara et al.
    Structural flexibility of the synaptobrevin-2 transmembrane domain promotes membrane fusion.
    1. Microbiology and Infectious Disease

    Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and rectal reservoirs

    Eva Malatinkova et al.
    An early start to long-term antiretroviral therapy limits the size of the HIV-1 reservoir more effectively than treatment that starts later.

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