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    1. Medicine

    Dynamics of compartment-specific proteomic landscapes of hepatotoxic and cholestatic models of liver fibrosis

    Marketa Jirouskova, Karel Harant ... Martin Gregor
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Chromosomes and Gene Expression
    2. Medicine

    LncRNA Snhg3 aggravates hepatic steatosis via PPARγ signaling

    Xianghong Xie, Mingyue Gao ... Xiaojun Liu
    LncRNA-Snhg3 regulates lipid metabolism by affecting chromatin accessibility which indicates that lncRNA-mediated epigenetic modification has a crucial role in the pathology of metabolic dysfunction-associated fatty liver disease.
    1. Cell Biology

    A Ctnnb1 enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epithelia

    Xiaojiao Hua, Chen Zhao ... Yan Zhou
    An enhancer-dependent transcriptional machinery finely tunes the expression of Ctnnb1 in intestinal crypts, thereby balancing homeostasis and tumorigenesis of intestinal epithelia.
    1. Cancer Biology

    TAK1-mediated phosphorylation of PLCE1 represses PIP2 hydrolysis to impede esophageal squamous cancer metastasis

    Qianqian Ju, Wenjing Sheng ... Cheng Sun
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cancer Biology

    Exploring the role of the immune microenvironment in hepatocellular carcinoma: Implications for immunotherapy and drug resistance

    Yumin Fu, Xinyu Guo ... Lianxin Liu
    The immune microenvironment has a pivotal role in hepatocellular carcinoma (HCC) progression and immune therapy resistance, and targeting this complex milieu holds great promise for improving therapeutic outcomes and patient prognoses in HCC management.
    1. Immunology and Inflammation

    A hepatocyte-specific transcriptional program driven by Rela and Stat3 exacerbates experimental colitis in mice by modulating bile synthesis

    Jyotsna, Binayak Sarkar ... Rajesh S Gokhale
    Studies in murine model identify hepatic Rela-Stat3 network as a potential driver of gut inflammation and a novel therapeutic target for inflammatory bowel disease, offering new insights into liver-gut crosstalk.
    1. Cell Biology
    2. Medicine

    Adventitial fibroblasts direct smooth muscle cell-state transition in pulmonary vascular disease

    Slaven Crnkovic, Helene Thekkekara Puthenparampil ... Grazyna Kwapiszewska
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology

    Loss of SPNS1, a lysosomal transporter, in the nervous system causes dysmyelination and white matter dysplasia

    Yoshinobu Ichimura, Yuki Sugiura ... Masaaki Komatsu
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Developmental Biology
    2. Genetics and Genomics

    The robust, high-throughput, and temporally regulated roxCre and loxCre reporting systems for genetic modifications in vivo

    Mengyang Shi, Jie Li ... Bin Zhou
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Biochemistry and Chemical Biology
    2. Stem Cells and Regenerative Medicine

    Targeted protein degradation systems to enhance Wnt signaling

    Parthasarathy Sampathkumar, Heekyung Jung ... Yang Li
    A novel targeted protein degradation system to achieve cell-type-specific enhancement of Wnt signaling.
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