Leslie Duplaquet, Catherine Leroy ... David Tulasne
MET acts as a dependence receptor in vivo by promoting hepatocyte apoptosis, a response induced by a caspase generated fragment able to favor calcium exchange between endoplasmic reticulum and mitochondria.
NOD-like receptor NLRP12 is a critical regulator of hepatocyte proliferation and its activation could be therapeutically used to suppress hepatocellular carcinoma.
ELYS, a multifunctional protein with critical roles in the cell cycle, is essential for the vigorous proliferation and survival of difficult-to-treat cancers carrying mutations in the KRAS oncogene, making it a compelling target for novel drug treatments.
Loss of hepatic Cdk1 leads to oxidative stress, increased fatty acids in blood, and hyperinsulinemia, which resulted in insulin resistance and hepatic steatosis, similar as in diabetes.
LISP2 expression marks the beginning of awakening of dormant hypnozoite to developing malaria liver stages, which are susceptible to a novel prophylactic drug, Plasmodium PI4K inhibitor.
Hyperphosphatemia, by itself and in the context of chronic kidney disease, contributes to iron restrictive anemia by directly targeting the liver and elevating proinflammatory cytokines and hepcidin, which contributes to widespread tissue injury, such as skeletal muscle wasting.
Glucocorticoid receptor directly regulates the transcriptional activity of peroxisome proliferator-activated alpha (PPARα) before birth in anticipation of the sudden shifts in the postnatal nutrient source and metabolic demands.
Ngoc-Hien Du, Alaaddin Bulak Arpat ... David Gatfield
In the liver, microRNAs exert widespread functions in the modulation of phases and amplitudes of clock-controlled gene expression, but their influence on the core clock is remarkably mild.
Chitinase 3-like-1 promotes Kupffer cells to recruit platelets, thereby contributing to liver injury, and serves as a therapeutic target in acetaminophen-induced liver injury.
