Integrating chromatin accessibility and gene expression data into context-specific regulatory networks can provide better regulatory categories for heritability enrichment and relevant tissue identification.

Quasi-enveloped hepatitis A virions undergo clathrin-mediated endocytosis, followed by ALIX-dependent trafficking to lysosomes where the quasi-envelope is degraded, triggering uncoating of the RNA genome in association with lysosomal membrane rupture.

An essential role for ACAT in conferring 25HC-mediated protection against bacterial and viral infection has been uncovered.

SUV39H1 histone methyltransferase directly binds chromosome associated RNA to promote constitutive heterochromatin formation.

The mechanism triggering HBV membrane fusion involves ERp57, a cellular protein disulfide isomerase, and ultimately leads to the exposition of a fusion peptide that was identified in the pre-S1 determinant.

Nuclear receptor NHR-14 regulates the subcellular localization of the zinc transcription factor PQM-1 to coordinate innate immunity with iron sequestration during pathogen infection in C. elegans..

Antibody-mediated neutralisation of Gremlin-1 was ineffective in treating fibrosis in metabolic dysfunction-associated steatohepatitits, likely due to low hepatic expression in a subset of myofibroblasts and redundant Gremlin-1 signalling.

Store operated calcium entry is defective in hepatocytes of obese mice, and restoring this process is sufficient to improve glucose metabolism.