1,580 results found
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress

    Joseph M Cabral et al.
    Epigenetic restriction of herpes simplex virus occurs in a biphasic manner, in which ATRX maintains viral heterochromatin after an initial phase of chromatin deposition.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1

    Sean R Cuddy et al.
    Herpes simplex virus reactivates from a latent infection when neurons become hyperexcitable in response to an inflammatory cytokine known to be released during fever and stress.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract

    Joshua T Schiffer et al.
    A combination of detailed sampling and mathematical modeling suggests that the response of immune cells to reactivation of herpes simplex virus 2 is extremely rapid and effective within microscopic areas of genital skin.
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Structure of the transporter associated with antigen processing trapped by herpes simplex virus

    Michael L Oldham et al.
    Herpes simplex virus evades the immune response by inhibiting the TAP transporter with a peptide inhibitor ICP47 that has an extensive interface at the peptide translocation cavity and locks the transporter in an inactive state.
    1. Microbiology and Infectious Disease

    Herpes simplex type 2 virus deleted in glycoprotein D protects against vaginal, skin and neural disease

    Christopher Petro et al.
    An attenuated Herpes simplex type 2 virus deleted in glycoprotein D can be used as an effective vaccine to provide robust transferable humoral immunity and complete protection in murine intravaginal and skin infection models.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Insights into herpesvirus assembly from the structure of the pUL7:pUL51 complex

    Benjamin G Butt et al.
    A conserved viral protein complex that promotes membrane wrapping of nascent herpesvirus particles shows structural similarity to cellular membrane-remodelling proteins, suggesting functional mimicry.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    HSV-1 single-cell analysis reveals the activation of anti-viral and developmental programs in distinct sub-populations

    Nir Drayman et al.
    Single-cell analyses of cells infected by Herpes Simplex Virus 1 revealed extreme heterogeneity among infected cells, including the robust activation of developmental gene programs in highly infected cells.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Herpesviral lytic gene functions render the viral genome susceptible to novel editing by CRISPR/Cas9

    Hyung Suk Oh et al.
    CRISPR genome editing technology can efficiently introduce mutations into lytic and latent HSV genomes to block lytic replication and reactivation of latent herpes simplex virus genome though differential mechanisms.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation

    David Trombley McSwiggen et al.
    Transient DNA interactions by DNA-binding proteins are utilized by herpes simple virus as an alternative route to generate membraneless compartments in the nucleus without invoking phase separation.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Structured illumination microscopy combined with machine learning enables the high throughput analysis and classification of virus structure

    Romain F Laine et al.
    Machine learning in conjunction with super-resolution imaging allows for the first time to quantitatively analyse large and heterogenous virus samples structure at a high throughput and specificity.
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