613 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Conformational dynamics of the nucleotide binding domains and the power stroke of a heterodimeric ABC transporter

    Smriti Mishra et al.
    The conformational cycle of an ABC heterodimeric transporter reveals a divergence in the structural mechanism of ABC exporters.
    1. Cell Biology
    2. Neuroscience

    Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells

    David Moreno Delgado et al.
    Innovative approaches were used to identify the specific pharmacological properties of heterodimeric metabotropic glutamate receptors composed of mGlu2 and mGlu4 subunits, and reveal their existence in a neuronal cell line and in perforant path terminals.
    1. Cell Biology
    2. Developmental Biology

    BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis

    Hyung-Seok Kim et al.
    Endogenous BMP2/7 and BMP4/7 heterodimers form in vivo, and are the predominant functional ligand in many, if not all, tissues of developing mouse embryos.
    1. Developmental Biology

    Vg1-Nodal heterodimers are the endogenous inducers of mesendoderm

    Tessa G Montague, Alexander F Schier
    Nodal is assumed to be the sole inducer of mesendoderm, but the related signal Vg1 is as essential as Nodal in this process.
    1. Biochemistry and Chemical Biology

    Single-molecule functional anatomy of endogenous HER2-HER3 heterodimers

    Byoungsan Choi et al.
    Single-molecule immunoprecipitation method reveals that the high catalytic rate and multi-tasking capability make a concerted contribution to the strong signaling potency of the HER2-HER3 heterodimers.
    1. Structural Biology and Molecular Biophysics

    Exploring conformational equilibria of a heterodimeric ABC transporter

    M Hadi Timachi et al.
    A heterodimeric exporter exhibits conformational equilibria in the presence of nucleotides, suggesting a unified mechanistic model for the conformational cycle of ABC exporters.
    1. Cell Biology

    Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer

    Junke Liu et al.
    In mGlu heterodimers, an oriented asymmetrical activation revealed complex allosteric interaction between subunits.
    1. Developmental Biology

    Patterning and Axis Formation: Heterodimers reign in the embryo

    Benjamin Tajer, Mary C Mullins
    Experiments by three independent groups on zebrafish have clarified the role of two signaling factors, Nodal and Gdf3, during the early stages of development.
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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A single power stroke by ATP binding drives substrate translocation in a heterodimeric ABC transporter

    Erich Stefan et al.
    Single-turnover studies reveal quantitative insights into the inner mechanics and unfold hidden facets in the conformational coupling of ATP binding, hydrolysis, and substrate translocation by ABC transporters.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2

    Lucas Tafur et al.
    Cryo-EM structures of RNA polymerase I reveal considerable 'transformers-like' rearrangements where one subcomplex dissociates and is replaced by one domain of another subunit, possibly as an additional layer of transcriptional control.

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