595 results found
    1. Computational and Systems Biology

    Systematic integration of biomedical knowledge prioritizes drugs for repurposing

    Daniel Scott Himmelstein et al.
    Project Rephetio combines data integration and systematic analysis to enable drug repurposing predictions on an unprecedented scale.
  1. Cutting Edge: A network approach to mixing delegates at meetings

    Federico Vaggi et al.
    A network-based ‘speed dating’ approach can promote interactions between delegates at scientific meetings.
  2. Research: Gender bias in scholarly peer review

    Markus Helmer et al.
    Gender-bias in peer reviewing might persist even when gender-equity is reached because both male and female editors operate with a same-gender preference whose characteristics differ by editor-gender.
    1. Developmental Biology

    Neuroblasts: Flies do the locomotion

    Jennifer K Lovick et al.
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    1. Neuroscience

    Risk of punishment influences discrete and coordinated encoding of reward-guided actions by prefrontal cortex and VTA neurons

    Junchol Park, Bita Moghaddam
    Risk of punishment during reward seeking behavior is associated with a functional "disconnection" of the PFC-VTA circuit due to a transient loss of VTA-driven theta oscillation.
    1. Neuroscience

    Altered topology of neural circuits in congenital prosopagnosia

    Gideon Rosenthal et al.
    An innovative inter-subject stimulus-locked brain activation approach uncovers marked topological differences in a brain network of higher-order visual regions in individuals with a congenital impairment in face recognition compared with controls.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Temporal profiling of redox-dependent heterogeneity in single cells

    Meytal Radzinski et al.
    Analysis of aging yeast cells using the in-vivo roGFP2-based probe reveals redox-dependent heterogeneity, reflected in a bi-modal distribution of the oxidation status, differential growth and replication, as well as distinct proteomic and transcriptomic profiles.
    1. Neuroscience

    Targeting light-gated chloride channels to neuronal somatodendritic domain reduces their excitatory effect in the axon

    Jessica E Messier et al.
    A high axonal chloride concentration explains why activation of light-gated chloride channels causes neurotransmitter release, and a novel hybrid somatodendritic targeting motif ameliorates this phenomenon and improves their inhibitory function.
    1. Developmental Biology

    A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

    Meng Amy Li et al.
    A novel lncRNA (Ephemeron) is connected to known post-transcriptional and epigenetic regulators as part of an integrated machinery, which controls the timely exit from the naïve state of mouse embryonic stem cells.
    1. Neuroscience

    Locus coeruleus to basolateral amygdala noradrenergic projections promote anxiety-like behavior

    Jordan G McCall et al.
    Selective activation of locus coeruleus noradrenergic terminals drives anxiety-like behaviors through activation of β-adrenergic receptors in the basolateral amygdala.

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