773 results found
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease
    Tropical disease

    Tropical Disease: A Collection of Articles

    Edited by Prabhat Jha et al.
    eLife has published papers on many tropical diseases, including malaria, Ebola, leishmaniases, Dengue and African sleeping sickness.
  1. Toward publishing reproducible computation with Binder

    Binder makes it easy to include an interactive version of your analysis, with the supporting data and code, alongside a published paper.
    1. Neuroscience

    Chronic pain induces generalized enhancement of aversion

    Qiaosheng Zhang et al.
    Chronic pain distorts intensity coding in the anterior cingulate cortex to give rise to generalized anatomically nonspecific enhancement in pain aversion.
    1. Neuroscience

    MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders

    Adam J Harrington et al.
    Mice that lack the autism- and schizophrenia-linked gene MEF2C in cortical neurons have an imbalance of excitatory and inhibitory synapses, and impaired social and cognitive abilities.
    1. Chromosomes and Gene Expression

    H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers

    Dong Fang et al.
    Redistribution of the PRC2 complex in H3.3K27M mutant cells to poised enhancers contributes to the global reduction of H3K27me3 in cells expressing the mutant proteins.
    1. Neuroscience

    Loss of ZBTB20 impairs circadian output and leads to unimodal behavioral rhythms

    Zhipeng Qu et al.
    The zinc finger protein ZBTB20 is a morning and evening activity gating factor in mice.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading

    Dongqing Pan et al.
    The stoichiometry and mechanism of interactions of the Mis18 complex with M18BP1 was analysed to unveil the molecular basis of new CENP-A deposition during the G1 phase of the cell cycle.
    1. Computational and Systems Biology
    2. Developmental Biology

    Stochasticity in the miR-9/Hes1 oscillatory network can account for clonal heterogeneity in the timing of differentiation

    Nick E Phillips et al.
    Stochasticity introduced computationally into a gene expression oscillator creates heterogeneity in the time of differentiation of identical cells and offers robustness to the progenitor state and the outcome of cell division.
    1. Cell Biology

    Actin assembly ruptures the nuclear envelope by prying the lamina away from nuclear pores and nuclear membranes in starfish oocytes

    Natalia Wesolowska et al.
    Combined light and electron microscopy reveals a new function for Arp2/3-mediated actin assembly in nuclear envelope rupture, which leads to a separation of nuclear membranes and pores from the lamina.
    1. Cell Biology
    2. Plant Biology

    Evolutionarily unique mechanistic framework of clathrin-mediated endocytosis in plants

    Madhumitha Narasimhan et al.
    The examination of the ultra-structure and in vivo dynamics of endocytosis in plants reveal plants unique actin-independent, clathrin-mediated endocytosis mechanisms to overcome their unique physiological properties.

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