Proteins of the reticulon and REEP families, homologous to the products of human Hereditary Spastic Paraplegia disease genes, contribute to shaping and continuity of the axonal endoplasmic reticulum network in Drosophila.
Diana M Mitrea, Jaclyn A Cika ... Richard W Kriwacki
Nucleolar protein localization involves the phase separation within the nucleolar matrix via three types of multivalent features: acidic tracts, nucleic acid binding domains and arginine-rich low complexity sequences.
Emma J Fenech, Federica Lari ... John C Christianson
Interaction mapping of ubiquitin ligase complexes embedded in the endoplasmic reticulum membrane has identified interactors of RNF26 that influence innate immune signalling.
GABAergic neurons in the nervous system of C. elegans have been comprehensively mapped allowing analysis of regulatory factors that program GABAergic neuron identity.
Darya Task, Chun-Chieh Lin ... Christopher J Potter
Olfactory neurons of insects, once thought to express only a single type of olfactory receptor, exhibit widespread co-expression of receptors from multiple chemosensory gene families.
Hansen Wang, Lisa D Muiznieks ... Gerold Schmitt-Ulms
The cyclic neuropeptide somatostatin binds to human Aβ1-42 through an interface that critically relies on a specific tryptophan, thereby blocking the propensity of Aβ to aggregate, a critical step in the pathobiology of Alzheimer's disease.
Thibaud Dieudonné, Sara Abad Herrera ... Guillaume Lenoir
Single particle cryo-electron microscopy associated with functional studies reveal a critical role of N- and C-terminal tails in the autoinhibition of the disease-related ATP8B1-CDC50A lipid flippase, the possible role of phosphorylation in autoinhibition relief, and strong activation by PI(3,4,5)P3.