Browse the search results

Combining crystal structures with single-pore analysis of Fluc-family fluoride channel mutants demonstrates that Fluc channels have two separate fluoride ion permeation pathways within the channel complex.

The homomeric structure of human SWELL1 (LRRC8A) provides insights into properties of a novel chloride channel family.

Two mutations in TRPM3 resulting in developmental and epileptic encephalopathies result in a gain-of-channel function, which may lie at the basis of epileptic activity and neurodevelopmental symptoms in the patients.

An anion-selective ligand gated channel acts as a presynaptic auto-receptor to modulate vesicle release and neuronal excitation.

Disease-associated mutants of the TRPM3 ion channel are overactive, and they are inhibited by the antiepileptic medication primidone, offering a potential therapeutic intervention to treat this channelopathy.

Mice deficient in the TRPM6 channel suffer from impaired prenatal development, shortened lifespan, growth deficit and disturbed energy balance due to a defect in epithelial Mg²⁺ uptake, thus highlighting a pivotal role of TRPM6 in organismal Mg²⁺ homeostasis.

Methodology for the in vitro assembly of multimeric membrane proteins and the utility of the approach for generating heteromeric variants of homo-multimeric proteins is described.

Comparative genomics and three-dimensional protein modelling identify homologs of insect chemosensory receptors in unicellular eukaryotes and plants.

Mapping the ion permeation pathway within the internal pore of ATP-activated P2X receptor channels.

Structural studies revealing the organization of assemblies consisting of CALHM2 and CALHM4 subunits provide insight into the mechanism of heteromerization of large pore channels.