12 results found
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Assessing the danger of self-sustained HIV epidemics in heterosexuals by population based phylogenetic cluster analysis

    Teja Turk et al.
    A method to assess the risk of self-sustained HIV transmission in heterosexuals from phylogenetic and epidemiological data is developed and, when applied to the Swiss HIV epidemic, shows that this risk is negligibly small for Switzerland.
    1. Evolutionary Biology

    The genetic architecture of gene expression levels in wild baboons

    Jenny Tung et al.
    RNA sequencing of individuals within a wild baboon population reveals extensive power to detect functional regulatory variation, and suggests that the set of genes affected by such variation may be conserved across species.
    1. Neuroscience

    Hedonic processing in humans is mediated by an opioidergic mechanism in a mesocorticolimbic system

    Christian Buchel et al.
    The pleasure of rewards in humans is mediated by an opioidergic mechanism.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Population genomics of intrapatient HIV-1 evolution

    Fabio Zanini et al.
    Whole genome deep sequencing of many longitudinally sampled HIV-1 populations reveals that reversions towards ancestral HIV-1 genome sequences occur throughout the course of infection.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    A transmission-virulence evolutionary trade-off explains attenuation of HIV-1 in Uganda

    François Blanquart et al.
    Analysis of epidemiological data reveals that viral loads in newly HIV-1 infected individuals in Uganda have declined for two decades, and evolutionary modelling shows that attenuation of the virus explains this decline.
    1. Microbiology and Infectious Disease

    Longitudinal imaging of HIV-1 spread in humanized mice with parallel 3D immunofluorescence and electron tomography

    Collin Kieffer et al.
    Combined tissue clearing, 3D-immunofluorescence, and electron tomography spatially revealed the dynamics of early HIV-1 spread within lymphoid tissues of humanized mice at the resolution of single cells and individual virions.
    1. Neuroscience

    The modulation of savouring by prediction error and its effects on choice

    Kiyohito Iigaya et al.
    The anticipation of rewards turns out to have its own hedonic value, on top of that of the reward itself; a wide range of behavioral and neurophysiological data suggest that this anticipation is boosted by prediction errors.
    1. Microbiology and Infectious Disease

    Cohabiting family members share microbiota with one another and with their dogs

    Se Jin Song et al.
    Research on humans and dogs reveals that the communities of microorganisms found on the skin, on the tongue and in the intestine are affected differently by age and cohabitation.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

    Simon Langer et al.
    By inhibiting the activation of NF-κB, HIV-1 Vpu exerts much broader immunosuppressive effects than previously anticipated and may be an important determinant of chronic inflammation in HIV-1 infected individuals.
    1. Neuroscience

    Activation of the dopaminergic pathway from VTA to the medial olfactory tubercle generates odor-preference and reward

    Zhijian Zhang et al.
    The VTA-mOT DAergic pathway mediates a variety of naturalistic reward processes and different types of preferences including odor-preference.

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