123 results found
    1. Computational and Systems Biology

    Generative modeling of multi-mapping reads with mHi-C advances analysis of Hi-C studies

    Ye Zheng et al.
    A statistical model rescues multi-mapping reads with high accuracy and demonstrates their impact in all facets of the analysis of genome-wide high throughput conformation capture datasets.
  1. Philosophy of Biology: The challenges of big data biology

    Sabina Leonelli
    Understanding how data were collected and processed is an essential element of big data biology.
    1. Genetics and Genomics

    An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

    Tom G Richardson et al.
    A resource to systematically explore the association between overall genetic risk for 162 risk factors and disease with 551 outcomes.
    1. Neuroscience

    Visualization of currents in neural models with similar behavior and different conductance densities

    Leandro M Alonso, Eve Marder
    Visualization methods display the dynamics of the currents in conductance-based model neurons, and show how their contribution changes in response to perturbation.
    1. Neuroscience

    Control of entropy in neural models of environmental state

    Timothy H Muller et al.
    Evidence for neuromodulatory control of flexibility in human neural models.
    1. Computational and Systems Biology
    2. Neuroscience

    Bumblebee visual allometry results in locally improved resolution and globally improved sensitivity

    Gavin J Taylor et al.
    Bigger bumblebee eyes have better vision, yet their field of view, sensitivity, and resolution do not all simply scale up with eye size, being improved locally instead.
    1. Ecology
    2. Evolutionary Biology

    Quorums enable optimal pooling of independent judgements in biological systems

    James AR Marshall et al.
    Consideration of signal detection theory shows how decision ecology relates to optimal collective decisions, helping explain the prevalence of quorum-sensing in even the simplest collective systems, such as bacterial communities.
    1. Neuroscience

    Unsupervised discovery of temporal sequences in high-dimensional datasets, with applications to neuroscience

    Emily L Mackevicius et al.
    Building on simple unsupervised matrix factorization techniques, the seqNMF algorithm successfully recovers neural sequences in a wide range of simulated and real datasets.
    1. Neuroscience

    Computational modeling of brainstem circuits controlling locomotor frequency and gait

    Jessica Ausborn et al.
    A new computational model of brainstem control of locomotor speed and gait was developed to reproduce and explain recent experimental data and propose predictions for subsequent experimental testing.
    1. Developmental Biology

    Is it possible to reconstruct an accurate cell lineage using CRISPR recorders?

    Irepan Salvador-Martínez et al.
    Computer simulations reveal the potential and limitations of recently proposed CRISPR-based cell lineage recorders, and suggest how the recorders' design can be optimised to yield more accurate cell lineage trees.

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