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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A single K+-binding site in the crystal structure of the gastric proton pump

    Kenta Yamamoto et al.
    Crystal structures provide structural rationales for the transport stoichiometry of the gastric proton pump, which suffices the energy requirement for the generation of a million-fold proton gradient across the membrane.
    1. Neuroscience

    The hippocampus supports deliberation during value-based decisions

    Akram Bakkour et al.
    The deliberation involved in simple preference decisions, such as those between two familiar snacks, depends on the hippocampus.
    1. Neuroscience

    Sub-second dynamics of theta-gamma coupling in hippocampal CA1

    Lu Zhang et al.
    A combination of signal processing and machine learning form a new approach to classify oscillatory coupling in single cycles without averaging over time and to capture cycle-by-cycle changes in coupling.
    1. Ecology
    2. Evolutionary Biology

    Variable opportunities for outcrossing result in hotspots of novel genetic variation in a pathogen metapopulation

    Anna-Liisa Laine et al.
    In natural pathogen populations opportunities for sexual outcrossing vary, leading to spatial variation in genetic diversity and between-season survival.
    1. Computational and Systems Biology

    Metabolic network percolation quantifies biosynthetic capabilities across the human oral microbiome

    David B Bernstein et al.
    A novel metabolic network analysis method enables large-scale computational predictions of biosynthetic capabilities across the human oral microbiome, revealing a unique cluster of fastidious microorganisms and potential metabolic interdependencies.
    1. Genetics and Genomics

    The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay

    Karole N D'Orazio et al.
    Cue2 is an endonuclease that cleaves mRNA in the A site of the lagging ribosome upon ribosome collision events.
    1. Evolutionary Biology

    A non-archaeopterygid avialan theropod from the Late Jurassic of southern Germany

    Oliver WM Rauhut et al.
    A new taxon from the Late Jurassic of southern Germany represents the second volant bird known from that time period and documents the improvement of flapping flight in bird evolution.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Environmental heterogeneity can tip the population genetics of range expansions

    Matti Gralka, Oskar Hallatschek
    Environmental heterogeneity can dramatically reduce the efficacy of selection and alter the neutral evolutionary dynamics in microbial range expansions.
    1. Computational and Systems Biology

    Generative modeling of multi-mapping reads with mHi-C advances analysis of Hi-C studies

    Ye Zheng et al.
    A statistical model rescues multi-mapping reads with high accuracy and demonstrates their impact in all facets of the analysis of genome-wide high throughput conformation capture datasets.
  1. Philosophy of Biology: The challenges of big data biology

    Sabina Leonelli
    Understanding how data were collected and processed is an essential element of big data biology.