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    1. Cell Biology
    2. Microbiology and Infectious Disease

    Coupling chemosensory array formation and localization

    Alejandra Alvarado et al.
    Formation and cell pole-localization of chemotactic signaling-arrays is a coupled process mediated by ParP, which drives localized array-assembly and regulates the localization-dynamics of its network constituents.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Structure of bacterial cytoplasmic chemoreceptor arrays and implications for chemotactic signaling

    Ariane Briegel et al.
    Bacterial cytoplasmic chemoreceptors assemble into a sandwich of two hexagonally packed arrays.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Hepatitis B virus core protein allosteric modulators can distort and disrupt intact capsids

    Christopher John Schlicksup et al.
    Small molecule antivirals that drive assembly of HBV capsid protein can also bind to pre-assembled capsids causing them to change morphology or even break, suggesting a complex transduction of binding effects across the capsid.
    1. Cell Biology
    2. Neuroscience

    Genetic defects in β-spectrin and tau sensitize C. elegans axons to movement-induced damage via torque-tension coupling

    Michael Krieg et al.
    A conceptual framework and physical model shows how actin-spectrin networks and microtubule bundles can protect axons from mechanical stress.
    1. Cell Biology
    2. Physics of Living Systems

    Bridging the gap between single-cell migration and collective dynamics

    Florian Thüroff et al.
    A computational model, based on single-cell features like contractility and polarizability, quantitatively describes cellular dynamics from the single cell level up to small cohorts and confluent tissues.
    1. Neuroscience

    Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity

    Zohreh Farsi et al.
    Parallel measurements of pH gradient and membrane potential at the single vesicle level have revealed that the synaptic vesicle acidification is initiated by removal of its clathrin coat, which blocks vesicular ATPase activity.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A population-level invasion by transposable elements triggers genome expansion in a fungal pathogen

    Ursula Oggenfuss et al.
    The activation of transposable elements and relaxed purifying selection underpin an incipient expansion of the genome in populations of a major wheat pathogen.
    1. Physics of Living Systems

    Shape selection and mis-assembly in viral capsid formation by elastic frustration

    Carlos I Mendoza, David Reguera
    Nucleation, elasticity theory, and simulations were combined to construct a general phase diagram that elucidates the conditions for successful viral assembly and the key factors to prevent it.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Lateral interactions between protofilaments of the bacterial tubulin homolog FtsZ are essential for cell division

    Fenghui Guan et al.
    Structural and functional approaches unambiguously revealed physiologically relevant lateral interactions between FtsZ protofilaments.
    1. Cell Biology
    2. Physics of Living Systems

    Principles of self-organization and load adaptation by the actin cytoskeleton during clathrin-mediated endocytosis

    Matthew Akamatsu et al.
    An experimentally constrained multiscale mathematical model predicts that branched actin networks self-organize at endocytic sites and bend to produce force, which was verified with cryo-electron tomography of intact cells.