Alterations in mTOR signaling drive similar dysregulations in the critical mid-fetal neurodevelopmental processes of neurite outgrowth and cell migration in two distinct subsets of autism, idiopathic and 16p11.2 deletion.

Methods for screening hundreds of DNA sequences for enhancer activity have been extended for use in vivo, uncovering novel enhancer elements active in the early postnatal brain.

lncDACH1 is a novel regulator of sodium channel, which suppresses the membrane trafficking of Nav1.5 by disturbing the function of dystrophin.

RNAseq and ATACseq are utilized to identify transcription factors participating in striatal compartmentation into striosome and matrix, and roles for Stat1, Olig2, and Foxf2 are validated in vitro and in vivo.

Proteomic analysis of brain organoids from creatine transporter deficiency (CTD) patients enhance the understanding of CTD offering potential therapeutic targets and a robust foundation for continued research in the field.

Discovery of a novel long non-coding RNA overlapping the distal SOX17 enhancer (eSOX17) that plays an essential role in human endoderm development.