159 results found
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells

    Diana Gumber et al.
    Selective activation of FZD7 signaling with an engineered WNT mimetic promotes early developmental programs, including endodermal lineage specification, in human pluripotent stem cells.
    1. Neuroscience

    Live calcium and mitochondrial imaging in the enteric nervous system of Parkinson patients and controls

    An-Sofie Desmet et al.
    In contrast to previous post-mortem or fixed tissue histochemical reports, live calcium and mitochondrial imaging data suggest that the enteric nervous system is not generally affected in Parkinson's disease patients.
    1. Genetics and Genomics
    2. Neuroscience

    Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology

    Eric N Anderson et al.
    Traumatic injury leads to functional defects in nucleocytoplasmic transport and TDP-43 pathology in multiple model systems.
    1. Developmental Biology
    2. Neuroscience

    Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons

    Max Koppers et al.
    Multiple axonal guidance receptors control the local and selective translation of mRNAs by binding to ribosomes, specific mRNAs and RNA-binding proteins.
    1. Neuroscience

    Assembly rules for GABAA receptor complexes in the brain

    James S Martenson et al.
    A novel GABAAR assembly pathway that promotes synaptic inhibition is established and provides a molecular explanation for how GABAARs with distinct subunit compositions display distinct subcellular distributions.
    1. Neuroscience

    Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration

    Federica Storti et al.
    Lipid efflux by the retinal pigment epithelium is crucial for proper retinal integrity and function, and its impairment may contribute to diseases like age-related macular degeneration.
    1. Neuroscience

    Functional effects of distinct innervation styles of pyramidal cells by fast spiking cortical interneurons

    Yoshiyuki Kubota et al.
    Cortical interneurons inhibit pyramidal cells to a greater degree when they form synapses with the pyramidal cell body than when they form synapses with dendrites.
    1. Biochemistry and Chemical Biology
    2. Stem Cells and Regenerative Medicine

    The dyskerin ribonucleoprotein complex as an OCT4/SOX2 coactivator in embryonic stem cells

    Yick W Fong et al.
    A previously unrecognized transcriptional coactivator function of the dyskerin ribonucleoprotein complex and its associated small nucleolar RNA has been uncovered and mediates embryonic stem cell-specific transcription.
    1. Neuroscience

    Local circuit allowing hypothalamic control of hippocampal area CA2 activity and consequences for CA1

    Vincent Robert et al.
    Input conveying social novelty information from the hypothalamus controls hippocampal activity by recruiting a novel inhibitory circuit in hippocampal area CA2.
    1. Neuroscience

    Quantitative properties of a feedback circuit predict frequency-dependent pattern separation

    Oliver Braganza et al.
    The feedback inhibitory microcircuit of the dentate gyrus likely boosts pattern separation during gamma oscillations.

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