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    1. Stem Cells and Regenerative Medicine

    Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cells

    Stephanie F Bellmaine, Dmitry A Ovchinnikov ... Martin Pera
    Small molecule inhibition of stem cell differentiation in vitro provides novel insight into how DYRK1A loss disrupts human nervous system development.
    1. Developmental Biology

    Induction of human somatostatin and parvalbumin neurons by expressing a single transcription factor LIM homeobox 6

    Fang Yuan, Xin Chen ... Yan Liu
    Inducing expression of a single transcription factor LIM homeobox 6 showed efficient generation of human parvalbumin and somatostatin interneurons.
    1. Neuroscience

    A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients

    Yishan Sun, Sergiu P Paşca ... Ricardo E Dolmetsch
    A human cellular model of a prototypical form of intractable childhood epilepsy supports selective impairment of inhibitory neurons as a key pathophysiological mechanism.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Human adherent cortical organoids in a multiwell format

    Mark van der Kroeg, Sakshi Bansal ... Femke MS de Vrij
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome

    Pratibha Thakur, Martin Lackinger ... Joseph A Gogos
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Neuroscience

    Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration

    Xinde Zheng, Leah Boyer ... Tony Hunter
    Rapamycin treatment inhibits mTOR activity and preserves ATP levels in neurons derived from induced pluripotent stem cells from a maternally inherited Leigh syndrome patient.
    1. Cell Biology
    2. Neuroscience

    Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers

    Shenjie Wu, Nancy C Hernandez Villegas ... Randy Schekman
    A pathway of unconventional secretion for alpha-synuclein, a protein which may spread in the brain as part of the pathology of Parkinson’s disease.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Modeling the ACVR1R206H mutation in human skeletal muscle stem cells

    Emilie Barruet, Steven M Garcia ... Edward C Hsiao
    Novel human iPS cell derived and primary skeletal muscle stem cells show that abnormal ACVR1 activation increases osteogenic/ECM gene expression and impairs myofiber repair, while revealing muscle-specific regenerative properties.
    1. Neuroscience

    LRRK2 regulates synaptic function through BDNF signaling and actin cytoskeleton

    Giulia Tombesi, Shiva Kompella ... Elisa Greggio
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    7-Dehydrocholesterol-derived oxysterols cause neurogenic defects in Smith-Lemli-Opitz syndrome

    Hideaki Tomita, Kelly M Hines ... Libin Xu
    A 7-dehydrocholesterol-derived oxysterol in SLOS was found to profoundly impact neurogenesis during cortical development by interacting with glucocorticoid receptor, which points to new therapeutic approaches for SLOS by targeting the activities of this oxysterol.
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