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572 results found
    1. Cancer Biology
    2. Developmental Biology

    Coopted temporal patterning governs cellular hierarchy, heterogeneity and metabolism in Drosophila neuroblast tumors

    Sara Genovese et al.
    About twenty temporal patterning genes are identified that drive an irreversible differentiation trajectory governing the heterogeneity and proliferative properties of cells in neural tumors with an early developmental origin.
    1. Neuroscience

    A hierarchy of timescales explains distinct effects of local inhibition of primary visual cortex and frontal eye fields

    Luca Cocchi et al.
    The selective effect of local inhibition on diffuse patterns of brain connectivity can be accounted for by an intrinsic hierarchical ordering of cortical timescales.
    1. Neuroscience

    Recruitment of inhibition and excitation across mouse visual cortex depends on the hierarchy of interconnecting areas

    Rinaldo David D'Souza et al.
    The relative recruitment of excitatory and inhibitory neurons by cortico-cortical interareal pathways depends on the hierarchy of areas and the laminar location of the neurons.
    1. Neuroscience

    A suppression hierarchy among competing motor programs drives sequential grooming in Drosophila

    Andrew M Seeds et al.
    Gaining genetic control over neural modules that drive the grooming of each Drosophila body part reveals how mechanisms for selecting among competing behavioral choices are used to generate sequences of actions.
    1. Developmental Biology
    2. Evolutionary Biology

    A distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero-posterior patterning of esophagus striated muscle

    Glenda Comai et al.
    Tbx1-Isl1-Met defines a unique genetic hierarchy that regulates esophagus myogenesis and patterning in the mouse.
    1. Neuroscience

    The frequency gradient of human resting-state brain oscillations follows cortical hierarchies

    Keyvan Mahjoory et al.
    The strongest peak frequency of brain oscillations in a brain area decreases significantly, gradually and robustly along the posterior-anterior axis following the global hierarchy from early sensory to higher order areas.
    1. Physics of Living Systems
    2. Immunology and Inflammation

    Early life imprints the hierarchy of T cell clone sizes

    Mario U Gaimann et al.
    The rapid development of immune memory in infancy shapes the composition of T cell defenses throughout the human lifespan.
    1. Chromosomes and Gene Expression

    Cooperation between a hierarchical set of recruitment sites targets the X chromosome for dosage compensation

    Sarah Elizabeth Albritton et al.
    Gene regulatory elements can target a chromatin regulatory complex to a single chromosome in the genome through hierarchical specification and long distance cooperation.
    1. Microbiology and Infectious Disease

    The antigenic switching network of Plasmodium falciparum and its implications for the immuno-epidemiology of malaria

    Robert Noble et al.
    The first comprehensive analysis of antigenic switching in the malaria-causing parasite Plasmodium falciparum provides new insights into the process that prevents individuals from acquiring immunity to the disease.
    1. Neuroscience

    Increasing suppression of saccade-related transients along the human visual hierarchy

    Tal Golan et al.
    Similar to spontaneous eye blinks perceptual stability, despite small saccades, is related to actively silencing transients in the high-level ends of both ventral and dorsal visual cortices, while activity in low-level visual cortex remains unstable.

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