486 results found
  1. Meta-Research: Questionable research practices may have little effect on replicability

    Rolf Ulrich, Jeff Miller
    Although questionable research practices inflate false positive rates, they have little effect on replicability because they also increase power.
    1. Computational and Systems Biology
    2. Developmental Biology

    Topology-driven protein-protein interaction network analysis detects genetic sub-networks regulating reproductive capacity

    Tarun Kumar et al.
    Regulatory networks of genes controlling different aspects of insect reproduction have been identified by a systems-level analysis of quantitative phenotypic information obtained from the loss of individual cell signaling genes.
    1. Structural Biology and Molecular Biophysics

    Structure of the bacterial ribosome at 2 Å resolution

    Zoe L Watson et al.
    High-resolution maps and models of the bacterial ribosome provide new chemical insights into protein synthesis, and should enable the development of robust tools for cryo-EM structure modeling and refinement.
    1. Cell Biology

    SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism

    Ashutosh Kumar et al.
    LRRC8A is an essential component of a mechanoresponsive ion channel signaling complex that tunes skeletal muscle differentiation, muscle cell size, function and metabolic pathways to regulate adiposity and systemic glycemia.
    1. Developmental Biology
    2. Immunology and Inflammation

    Eater cooperates with Multiplexin to drive the formation of hematopoietic compartments

    Gábor Csordás et al.
    The mutual interaction between the basement membrane protein Multiplexin and the phagocytosis receptor Eater expressed by the immune cells drives the formation and maintenance of the hematopoietic tissues in Drosophila.
  2. Meta-Research: Evaluating the impact of open access policies on research institutions

    Chun-Kai (Karl) Huang et al.
    A longitudinal study of open access levels at 1,207 research institutions worldwide reveals high performing institutions in Latin America, Africa and Asia.
    1. Structural Biology and Molecular Biophysics

    Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis

    Trayambak Pathak et al.
    Colorectal tumors down-regulate the mitochondrial Na+/Ca2+/Li+ exchanger (NCLX) to alter mitochondrial Ca2+ signaling and initiate transcriptional and metabolic reprogramming that drives tumor chemo-resistance and metastasis.
    1. Stem Cells and Regenerative Medicine

    Regulation of stem/progenitor cell maintenance by BMP5 in prostate homeostasis and cancer initiation

    Mathieu Tremblay et al.
    Gata3 loss in prostate basal stem/progenitor cells upregulates BMP5 which is necessary and sufficient to sustain full self-renewal potential and its inhibition significantly delays both prostate and skin tumor progression.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    An ER translocon for multi-pass membrane protein biogenesis

    Philip T McGilvray et al.
    A set of ER-localized membrane proteins whose loss causes developmental diseases in humans, assemble with Sec61 into a translocon that facilitates the biogenesis of hundreds of different multi-pass membrane proteins.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Poultry farmer response to disease outbreaks in smallholder farming systems in southern Vietnam

    Alexis Delabouglise et al.
    Longitudinal monitoring of poultry farms in southern Vietnam reveals that when outbreaks occur with symptoms similar to highly pathogenic avian influenza, farmers respond by sending their chickens to market early.

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