1,116 results found
    1. Genetics and Genomics
    2. Neuroscience

    Sex-determining genes distinctly regulate courtship capability and target preference via sexually dimorphic neurons

    Kenichi Ishii, Margot Wohl ... Kenta Asahina
    Sex-specific characteristics of the fruit fly courtship behavior are not specified by a single binary switch, but as a combination of traits that are modularly specified by separable genetic switches.
    1. Neuroscience

    Integrative frontal-parietal dynamics supporting cognitive control

    Derek Evan Nee
    Analysis of human fMRI data reveal that intermediary areas within the fronto-parietal control network (FPCN) are critical for integrating control processing, cognitive ability, and amenability to neuromodulation.
    1. Neuroscience

    Ventral hippocampal projections to the medial prefrontal cortex regulate social memory

    Mary L Phillips, Holly Anne Robinson, Lucas Pozzo-Miller
    Input from the ventral hippocampus to the medial prefrontal cortex regulates social memory in wild type mice and atypically-strengthened input causes social memory dysfunction in Rett syndrome mice.
    1. Neuroscience

    Dysfunctional hippocampal-prefrontal network underlies a multidimensional neuropsychiatric phenotype following early-life seizure

    Rafael Naime Ruggiero, Danilo Benette Marques ... Joao Pereira Leite
    The enduring impacts of early-life seizures on cognition and behavior are not attributed to neuronal loss but to disrupted hippocampus-prefrontal cortex network dynamics, heightened neuroinflammation, and altered dopaminergic transmission.
    1. Cell Biology

    Ubiquitination drives COPI priming and Golgi SNARE localization

    Swapneeta S Date, Peng Xu ... Todd R Graham
    The ability of COPI to bind polyubiquitin is a key determinant for SNARE incorporation into intracellular vesicles and for maintenance of a functional Golgi complex.
    1. Cell Biology

    Scaling of subcellular actin structures with cell length through decelerated growth

    Shane G McInally, Jane Kondev, Bruce L Goode
    The size of a subcellular structure, yeast actin cables, scales with the linear dimensions of the cell, which is achieved by feedback control of their growth rate.
    1. Evolutionary Biology

    RNA chaperones buffer deleterious mutations in E. coli

    Marina Rudan, Dominique Schneider ... Anita Krisko
    The overexpression of RNA chaperones, including several DEAD box RNA helicases, enhances the fitness of mutationally compromised E. coli strains.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation

    Lindsay B Case, Milagros De Pasquale ... Michael K Rosen
    Biochemical and cell biological data suggest a model of nascent integrin adhesion complex formation based on synergistic phase separation of pathways surrounding the focal adhesion kinase (FAK) and the adaptor protein p130Cas.
    1. Neuroscience

    Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila

    Magda L Atilano, Sebastian Grönke ... Linda Partridge
    Modulation of insulin signalling could be an effective therapeutic approach against hexanucleotide repeat expansion related to c9ALS/FTD neurodegenerative diseases.
    1. Developmental Biology
    2. Immunology and Inflammation

    Eater cooperates with Multiplexin to drive the formation of hematopoietic compartments

    Gábor Csordás, Ferdinand Grawe, Mirka Uhlirova
    The mutual interaction between the basement membrane protein Multiplexin and the phagocytosis receptor Eater expressed by the immune cells drives the formation and maintenance of the hematopoietic tissues in Drosophila.

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